University Of Oklahoma

This study tests whether disulfiram, a drug already approved for alcohol use disorder, can safely reduce joint inflammation in people with rheumatoid arthritis (RA) who are overweight. Researchers believe disulfiram may block a specific inflammatory pathway that worsens RA. Twent…

This study works with American Indian communities to help more people get a colonoscopy after a positive screening test. The goal is to catch colorectal cancer early and reduce high death rates. About 446 people will take part, and researchers will test a program to improve follo…

This study aims to increase the number of Native Americans who get a follow-up colonoscopy after an abnormal home stool test. Colorectal cancer is a leading cause of cancer death, and Native Americans are affected more than others. Researchers will work with the community to crea…

This early study tests whether selpercatinib, a drug already used for certain cancers, can help with severe weight loss and poor appetite (cachexia) in people with advanced lung, colon, or pancreatic cancer. Seven participants will take the drug twice daily for 12 weeks while res…

This study tests if a ketamine oral rinse can relieve pain from mouth sores (mucositis) caused by radiation therapy in head and neck cancer patients. About 62 adults receiving radiation will use the rinse and report their pain levels. The goal is to see if this simple rinse impro…

This study tests whether adding echothiophate eye drops to standard atropine treatment can improve vision in children aged 3 to 17 with refractory amblyopia (lazy eye that hasn't improved with usual care). Twenty participants will use atropine in the stronger eye for 4 weeks; if …

This study tests three types of tinted lenses—FL41 glasses, Biomedics55 contacts, and Altius grey-green contacts—to see which works best for people with light sensitivity (photophobia). About 200 adults who have used FL41 glasses before will rate their light sensitivity on a scal…

This study tests whether adding nicotine lozenges to standard smoking-cessation medication (varenicline) and using a smartphone app with medication reminders helps more people quit smoking. About 500 adults who smoke daily will be randomly assigned to different treatment combinat…