Second Xiangya Hospital Of Central South University

This study tests whether adding the drug cofrogliptin to standard treatment (metformin, insulin, and vitamin D3) can help preserve beta-cell function in adults with latent autoimmune diabetes (LADA). Over 52 weeks, 84 participants will take either cofrogliptin or a placebo, and r…

This study tests whether a medication called chiglitazar sodium, combined with healthy lifestyle changes, can help people with prediabetes return to normal blood sugar levels. About 472 adults with prediabetes will take either the drug or a placebo for 52 weeks, along with lifest…

This phase 2 trial tests whether the cancer drug sorafenib can help people newly diagnosed with type 1 diabetes keep making their own insulin. Ten adults aged 18-60 will receive either sorafenib or a placebo daily, along with their usual insulin. The study measures changes in ins…

This study tests whether a non-invasive brain stimulation technique called rTMS can improve cognitive flexibility—the ability to adapt thinking—in people with major depression. 105 participants will receive either active stimulation to two brain areas, active stimulation to one a…

This study tests whether a daily supplement of sulforaphane, a compound found in broccoli sprouts, can improve negative symptoms (like lack of motivation) and thinking problems in people with schizophrenia. Sixty participants aged 12 to 45 who are stable on antipsychotic medicati…

This pilot study tests a 4-week program based on acceptance and commitment therapy (ACT) for women who have experienced a miscarriage, stillbirth, or newborn death within the past year. The program includes six sessions plus a booster, combining in-person and video meetings. Rese…

This pilot study tests an online program for parents of children with hearing loss who have recently had cochlear implant surgery. The program combines education about implant care and communication strategies with Acceptance and Commitment Therapy (ACT) to help parents manage st…

This study looks at 45 adults with migraine and a small hole in the heart (PFO). Researchers will use brain scans and thinking tests to see if closing the hole changes brain activity, mood, and migraine symptoms over a year. The goal is to understand the link between PFO and migr…

This study looks at 700 adults with trigeminal neuralgia who had a balloon compression procedure to relieve facial pain. Researchers will use machine learning to analyze past patient data and create a model that predicts if pain will come back. The goal is to identify key factors…

This observational study will test whether a breathing exercise before anesthesia can predict low blood pressure in 86 elderly patients (65+). Researchers will measure pulse pressure variation during forced inhalation and see if it matches later drops in blood pressure. The goal …