Regina Elena Cancer Institute

This phase 2 trial tests whether adding chest radiotherapy to maintenance immunotherapy (atezolizumab) can better control extensive-stage small cell lung cancer. About 37 adults whose cancer shrank after initial chemo-immunotherapy will receive targeted radiation to the chest alo…

This study looks at whether using a piece of the patient's own tissue (a flap) to reinforce the closure after removing the voice box can reduce the risk of a throat leak (fistula). About 102 people whose throat cancer has returned after radiation or chemoradiation will be randoml…

This study tests whether adding vitamin K, α-lactalbumin, and D-chiro-inositol to standard calcium and vitamin D supplements can improve bone health in women with breast cancer who are on hormone therapy. These women are at higher risk for bone loss and fractures. The trial will …

This study looks at whether a blood test called liquid biopsy can quickly find genetic changes in people with advanced lung cancer. About 70 adults will give a blood sample, and researchers will compare the results to standard tissue biopsies. The goal is to see if this approach …

This study looks at how the body's metabolism might influence whether immunotherapy drugs work in people with non-small cell lung cancer. Researchers will collect and analyze tissue samples from 150 patients to compare those who respond to treatment with those who don't. The goal…

This study uses lab-grown tumor samples from 5 lung cancer patients to test whether natural compounds (resveratrol and artichoke extract) can make immunotherapy work better and cause fewer side effects. The goal is to find better drug combinations, not to cure the disease directl…

This study is collecting blood and tumor samples from 40 people with HPV-related oropharynx cancer to find biological markers that could predict how the disease will progress. Researchers will measure HPV DNA levels in the blood and analyze immune cells to better understand the b…

This study looks at three small molecules (miRNAs) that may help stop glioma, a type of brain tumor, from growing and spreading. Researchers will test these molecules in cells from 10 patients to see how they affect tumor behavior and response to standard treatments like radiatio…

This study is for people with metastatic triple-negative breast cancer who are already receiving the drug sacituzumab govitecan as part of their routine care. Researchers want to see how well the drug works in everyday practice and find biological markers (biomarkers) that predic…

This pilot study is looking at whether levels of a common virus called TTV can help predict how well immunotherapy works in people with advanced kidney cancer. Researchers will measure TTV levels in 20 patients before and during their first immunotherapy treatment. The goal is to…

This study is testing whether tumor tissue from endometrial cancer patients can be successfully turned into organoids (tiny lab-grown models) after being transported from other hospitals. About 20 adults with endometrial cancer will provide a sample during their standard surgery.…

This study takes small tissue samples from 24 women with cervical cancer and grows them into mini tumors called organoids. These organoids act like avatars to test which drugs work best, aiming to avoid unnecessary radiation and its side effects. The goal is to learn more about t…