Northwestern University

This study aims to help 2,000 adults in Chicago's South Side better control their high blood pressure. The program brings proven heart-health strategies into local churches and clinics, led by community health workers. The goal is to make blood pressure management easier and more…

This early-phase trial tests whether giving multiple doses of a special stem cell therapy (NSC-CRAd-S-pk7) directly into the brain is safe for people with newly diagnosed high-grade glioma. Participants receive the therapy before, during, and after standard radiation and chemothe…

This study looks at whether breathing pure oxygen in a pressurized chamber (hyperbaric oxygen therapy) can help people hospitalized with a moderate to severe ulcerative colitis flare. About 126 adults will receive either real or sham oxygen sessions alongside standard care. The g…

This study tests whether high-intensity treadmill exercise can slow the worsening of motor symptoms in people with early-stage Parkinson's disease. 370 participants who have not yet started medication will be assigned to either moderate or high-intensity treadmill workouts four t…

This study tests two programs to help young people aged 15-24 in Nigeria find out if they have HIV and get treatment. One program focuses on finding new HIV cases and linking them to care, while the other helps those already diagnosed stay on treatment and achieve viral suppressi…

This study compares the hormone therapy elacestrant alone versus elacestrant combined with a CDK4/6 inhibitor (palbociclib, abemaciclib, or ribociclib) in 174 people with ER+/HER2- advanced or metastatic breast cancer who have already used a CDK4/6 inhibitor. The goal is to see i…

This study tests whether artificial intelligence (AI) can help doctors choose the right radiation dose for lung tumors. About 70 people with lung cancer or tumors that spread to the lung will receive stereotactic body radiation therapy (SBRT), with the dose guided by an AI algori…

This study tests a program that combines peer support and phone-based tools to help young men who have sex with men and young transgender women (ages 15-29) in Nigeria stick with their HIV treatment and lower their virus levels. Participants will receive guidance from trained pee…

This study compares two common surgeries for removing kidney stones: mini-PCNL and ureteroscopy with a special suction tube. About 80 adults with stones between 1 and 3 cm will take part. The main goal is to see which procedure leaves fewer leftover stones, as seen on a CT scan.

This study tests a drug called WP1066 combined with radiation therapy for people with newly diagnosed glioblastoma, an aggressive brain cancer. The drug targets a protein that helps the tumor grow and hide from the immune system. About 39 participants will receive the combination…

This trial tests a new way to treat glioblastoma, an aggressive brain cancer. A device placed in the skull uses ultrasound to temporarily open the blood-brain barrier, allowing immune-boosting drugs to reach the tumor. The study involves 25 adults who have completed radiation, an…

This study looks at whether adding a GLP-1 agonist (a type of diabetes drug) to the MS treatment ocrelizumab can reduce disability progression in people with multiple sclerosis. Researchers will track 100 adults with MS over 72 weeks to see if the combination slows worsening of s…

This study tests whether adding PET-guided radiation to standard hormone therapy can better control metastatic prostate cancer. About 125 men with hormone-sensitive prostate cancer that has spread will be randomly assigned to standard care alone or standard care plus radiation to…

This study tests a web-based toolkit called CONNECT designed to help rural older adults who have survived cancer manage emotional distress and anxiety. The toolkit provides interactive activities, educational materials, and personalized mental health resource recommendations. Res…

This study looks at whether the way a doctor talks about an epidural steroid injection affects how much pain relief a person feels. People with leg pain from back problems will be randomly assigned to get the injection with either a very positive description or a more neutral one…

This study tests whether an 8-week mindfulness program, adapted for African American adults, can improve depressive symptoms and blood pressure control. About 60 participants from Chicago's South Side will learn stress management techniques like deep breathing and meditation. The…

This study tests whether taking pumpkin seed oil extract can improve bladder function in people with overactive bladder (OAB). Researchers at Northwestern University will give 40 adults the supplement for 12 weeks and track changes using patient surveys. The goal is to see if thi…

This study looks at whether having a physical therapist in the emergency department (ED) can help people with low back pain get faster care. About 140 adults with recent back pain will either see a PT in the ED or get usual care. The main goal is to see if this approach is practi…

This study tests whether a nerve block (stellate ganglion block) or the medication ketamine, alone or together, can reduce headaches and PTSD symptoms in people with traumatic brain injury. About 175 adults will receive either real treatments or sham procedures to see which works…

This study explores whether dream yoga practices, like lucid dreaming, can improve sleep and reduce anxiety. About 70 healthy adults with mild anxiety will use virtual reality and home sleep devices to learn these techniques. The goal is to understand how these practices affect b…

This study looks at whether text messages can encourage teenagers (ages 13-19) to get tested for HIV. About 360 teens who have had sex but never been tested will receive either helpful texts or general health information. Researchers will then check if more teens in the text grou…

This study tests whether a cone-shaped blood pressure cuff placed on the forearm gives more accurate readings than the standard cylindrical cuff on the upper arm in pregnant women. Researchers will enroll 110 women with different body sizes and blood pressure levels to see if the…

This study looks at how people with anxiety or depression react to uncertain situations. Researchers will use a one-time mental exercise to see if it changes decision-making and brain activity. About 140 adults aged 25-60 who struggle with uncertainty will participate. The goal i…

This study looks at 180 people with knee osteoarthritis to see if brain scans, knee MRIs, and pain tests can predict who will get good pain relief from duloxetine, celecoxib, or a placebo. Participants take one of these for about 20 weeks and report their pain levels. The goal is…

This study looks at whether a special training program can help addiction clinics use contingency management—a proven reward-based approach—to treat stimulant use. About 76 clinics will be randomly assigned to receive the program, and researchers will track how many patients and …

This study looks at how the brain changes after a stroke and how those changes affect arm and hand movement. Researchers will use brain scans and movement tests at several time points over six months in 120 adults who had a stroke. The goal is to find early signs that can predict…