National Institute Of Mental Health (nimh)

This study tested whether combining a non-invasive brain stimulation technique called rTMS with cognitive therapy can help treat major depression. Researchers used MRI scans to personalize the brain target for each participant. 32 adults with depression took part in daily session…

This study looked at whether a drug called LY500307 can prevent mood symptoms in postmenopausal women who had depression during perimenopause and became depressed again after stopping estrogen therapy. 74 healthy women aged 45-65 took either the drug or a placebo for 3 weeks whil…

This study looked at whether the drop in pregnancy hormones after childbirth triggers mood problems in women who have had postpartum depression before. Researchers created a temporary hormone environment similar to pregnancy and then stopped it to see how mood changed. The goal w…

This large study from the National Institute of Mental Health looks at how genes and brain function work together in people with schizophrenia and their siblings. The goal is to find the genes that increase risk and understand how they affect the brain. Nearly 5,000 participants …

This study looked at how the COVID-19 pandemic and related changes, like social distancing, affected people's mental health. Over 3,600 adults completed online surveys every two weeks for up to six months. The goal was to understand the link between pandemic-related stress and me…

This study aims to understand the biological causes of schizophrenia by using brain scans like PET and MRI. Researchers temporarily stop medication in some participants to see how the illness affects the brain without drug interference. 648 adults with schizophrenia were admitted…

This study aimed to understand the brain and genetics behind autism spectrum disorders (ASD). Researchers compared brain scans, thinking tests, and DNA from 678 people with ASD, healthy volunteers, and their parents. The goal was to find links between brain activity, behavior, an…

This study looked at how cooling the brain and timing brain stimulation with brain waves can change brain activity. Healthy adults wore a cooling cap or had brain waves measured while receiving mild magnetic pulses. The goal was to learn more about how the brain works, not to tre…

This study used advanced brain imaging (MRI and MEG) to look for differences in brain structure, chemistry, and activity between people with schizophrenia and healthy volunteers. Over 3,200 adults took part. The goal was to better understand the brain changes linked to schizophre…

This study tested different ways to apply non-invasive brain stimulation (like magnetic pulses) in 83 healthy adults aged 18-65. The goal was to learn how to make these techniques more effective for diagnosing and treating brain disorders. Participants completed tasks, had brain …

This study used PET scans to look at dopamine and blood flow in the brains of 502 people, including healthy volunteers and those with Parkinson's disease or schizophrenia. The goal was to understand how these conditions affect brain function and to compare inherited versus non-in…

This study looked at nearly 2,000 people from the community to understand how depression, anxiety, and migraine are passed down through families. Researchers interviewed family members of all ages, including children as young as 8, to track patterns of these conditions over time.…

This study looked at how certain brain receptors (dopamine D1 and D2/3) work in people with schizophrenia compared to healthy volunteers. Researchers used special brain scans (PET and MRI) to measure these receptors. The goal was to better understand what causes schizophrenia, wh…

This study looked at how hormone changes around menopause affect mood and behavior in women. Over 1,100 women participated, including those with depression symptoms and healthy volunteers. Researchers used surveys and blood tests to track mood and hormone levels, aiming to better…

This study used brain scans (PET) to see how the front part of the brain works during thinking tasks. It included over 1,000 healthy volunteers and people with schizophrenia or Parkinson's disease. The goal was to learn more about brain activity, not to test a treatment.

This study tested a set of questions to better identify suicide risk in young people aged 8 to 17 with autism or other neurodevelopmental disorders. Researchers asked 278 participants and their parents about thoughts of self-harm and understanding of death. The goal is to create …

This study used brain imaging (fMRI) to see how children's brains react during emotional tasks and whether those reactions are linked to their temperament. Researchers studied children from infancy to age 60, focusing on how brain activity might relate to risk for mood and anxiet…

This study aimed to better understand premenstrual syndrome (PMS) and its severe form, PMDD, by evaluating over 1,500 women. Participants completed interviews, mood ratings, and hormone tests to identify what causes mood changes before menstruation. A subgroup with severe symptom…

This study looked at how the COVID-19 pandemic affected the mental health of 193 Amish and Mennonite adults who already had depression, anxiety, or bipolar disorder. Participants filled out surveys about their symptoms and pandemic-related stress over two years. The goal was to u…