New hope for menopause mood swings: drug may prevent depression relapse
NCT ID NCT03689543
First seen Nov 01, 2025 · Last updated Jun 12, 2026 · Updated 31 times
Summary
This study looked at whether a drug called LY500307 can prevent mood symptoms in postmenopausal women who had depression during perimenopause and became depressed again after stopping estrogen therapy. 74 healthy women aged 45-65 took either the drug or a placebo for 3 weeks while researchers tracked their mood. The goal was to see if targeting a specific estrogen receptor in the brain could ease withdrawal-related mood issues.
Disclaimer
Read more
Show less
This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for PERIMENOPAUSE-RELATED DEPRESSION are added.
By submitting, you agree to our Terms of use
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
By submitting, you agree to our Terms of use
Locations
-
National Institutes of Health Clinical Center
Bethesda, Maryland, 20892, United States
Conditions
Explore the condition pages connected to this study.