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Brain scans reveal clues to Kids' temperament and emotional health

NCT ID NCT00060775

Knowledge-focused Sponsor: National Institute of Mental Health (NIMH) Source: ClinicalTrials.gov ↗

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Sep 02, 2026 · Updated 12 times

Summary

This study used brain imaging (fMRI) to see how children's brains react during emotional tasks and whether those reactions are linked to their temperament. Researchers studied children from infancy to age 60, focusing on how brain activity might relate to risk for mood and anxiety disorders. The goal was to better understand the connection between temperament, brain function, and emotional health.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

550 people

The number who actually took part.

Started

Nov 2003

Lead sponsor

A government research agency

The lead sponsor is the US National Institutes of Health.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Community sample

Ages

2 months to 60 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

* INCLUSION CRITERIA: * Consent: Can give consent/assent. * Age: 2 months-14 months; 7-60 years * Children in Cohort 4: Age: 9-11 years * IQ: All subjects will have IQ greater than 70. (exception: infants will not need to meet this criteria) * Psychopathology: all subjects will be free of lifetime history of psychosis and pervasive developmental disorder * Specific to infant cohort: between the ages of 4 and 14 months of age and is free of any known developmental disability or medical condition EXCLUSION CRITERIA: * Any chronic or acute medical condition severe enough to interfere with task performance or completion of questionnaires; Any medical condition that increases risk for MRI (e.g. pacemaker, metallic foreign body in eye, dental braces) * Any medical condition that increases risk for MRI (e.g. pacemaker, metallic foreign body in eye, dental braces). * Any current axis I psychiatric disorder necessitating acute treatment. * Claustrophobia * Pregnancy * Specific to infant cohort: 1. Was born prematurely, before 36 weeks gestation 2. Had a birth weight significantly below normal for gestational age 3. Has any known developmental disability or medical condition 4. Has any metallic objects in their body (e.g., Has implanted electrical devices, brain stimulators, some types of dental implants, aneurysm clips (metal clips on the wall of a large artery), metallic prostheses (including metal pins and rods, heart valves, and cochlear implants), implanted delivery pump, 5. Comes from a home where the primary language spoken is not English * NIMH employees and staff and their immediate family members will be excluded from the study per NIMH policy.

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Conditions

The condition(s) this trial relates to.

Depression

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Developmental psychology

Contacts and locations

Locations

  • National Institutes of Health Clinical Center

    Bethesda, Maryland, 20892, United States