National Institute Of Mental Health (nimh)

This study tested a new approach for treating major depression that did not fully respond to standard medications. Researchers combined two treatments: magnetic brain stimulation (rTMS) guided by a person's own brain scan, and a computer-based talk therapy session, delivered at t…

This study aimed to test a short questionnaire designed to identify suicide risk in children and teenagers with autism or similar conditions. Researchers worked with 278 youth and their parents to see if the questions accurately detected thoughts of self-harm. The goal is to crea…

This study tested if a new experimental drug could prevent mood symptoms from coming back when women with a history of perimenopausal depression stopped taking estrogen. Researchers gave 74 healthy, postmenopausal women estrogen patches for three weeks, then randomly gave them ei…

This completed study aimed to understand how brain activity changes. Researchers tested if cooling the scalp with a special cap or delivering magnetic brain stimulation at specific moments in a person's brain wave cycle could change how the brain responds. They studied healthy vo…

This study aimed to better understand how autism spectrum disorders affect brain function and thinking by observing participants, not treating them. Researchers enrolled 678 people, including those with autism, healthy volunteers, and their parents, to complete interviews, thinki…

This large, completed study aimed to understand the genetic and brain function factors behind schizophrenia and related disorders. Researchers compared patients, their siblings, and healthy volunteers to identify genes that might increase risk and affect thinking skills. The goal…

This study aimed to understand if sudden hormone changes after pregnancy trigger postpartum depression. Researchers gave hormones to 74 women with and without previous postpartum depression, then stopped them to mimic childbirth. They measured mood changes to see if hormone withd…

This study aimed to understand how mood disorders, anxiety, and migraines run in families. Researchers interviewed nearly 2,000 participants, including children and adults, to identify patterns and risk factors across generations. The goal was to gather knowledge to help improve …

This study used brain scans (fMRI) to understand how a person's basic temperament might be connected to their brain's activity. Researchers looked at children and adults to see if certain patterns of brain response during emotional tasks could help explain why some people are mor…

This study aimed to understand why some women develop depression and mood disorders during the transition to menopause. Researchers observed and compared over 1,100 perimenopausal women, some with depression and some without, to see if changes in hormones like estrogen were conne…

This study used special brain scans (PET scans) to measure dopamine activity and blood flow in the brains of healthy volunteers, people with Parkinson's disease, and people with schizophrenia. Researchers compared these measurements across groups to better understand how dopamine…

This study aimed to understand the biological basis of schizophrenia by seeing how the illness itself affects the brain, separate from the effects of medication. Researchers temporarily stopped antipsychotic drugs for 648 participants with schizophrenia in a closely monitored hos…

This study aimed to improve non-invasive brain stimulation (NIBS) techniques, which have potential for treating brain disorders. Researchers worked with 83 healthy volunteers to test different stimulation settings and measure brain responses using MRI, EEG, and simple tasks. The …

This study used advanced brain imaging (PET scans) to see how the frontal lobe works during thinking tasks. It compared healthy volunteers to people with conditions like schizophrenia and Parkinson's disease to understand brain function differences. The goal was to gather knowled…

This study aimed to better understand brain disorders like schizophrenia by comparing detailed brain scans of patients to those of healthy volunteers. Researchers used advanced MRI and MEG imaging technology to look for differences in brain structure, chemistry, and activity. The…

This study aimed to better understand how brain chemistry differs in people with schizophrenia. Researchers used special brain scans (PET and MRI) to measure dopamine receptors in 283 participants, including healthy volunteers and people with schizophrenia. The goal was to gather…