Can a new drug stop mood crashes after estrogen withdrawal?
NCT ID NCT03689543
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This study looked at whether a drug called LY500307 (an ER beta agonist) could prevent mood symptoms in postmenopausal women who had depression during perimenopause and then stopped using estrogen. 74 women took estrogen patches for 3 weeks, then either the study drug or a placebo for 3 weeks. Researchers tracked their mood and depression scores to see if the drug helped avoid mood dips.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Estradiol patch and an ER beta agonist (LY500307)
- What this could lead to
- If it works, this could point toward a treatment to prevent mood swings in women who stop estrogen therapy after perimenopausal depression.
- What could go wrong
- This is a small, early-phase study (74 participants) with a specific group, so results may not apply widely. The drug may not prevent mood symptoms or could have side effects.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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National Institutes of Health Clinical Center
Bethesda, Maryland, 20892, United States
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