Jazz Pharmaceuticals

This study is testing whether adding an experimental drug called zanidatamab to standard chemotherapy helps eliminate HER2-positive breast cancer before surgery. Researchers will enroll 125 people with early-stage breast cancer to see if this combination leads to better outcomes.…

This large, late-stage trial is testing whether a new drug, zanidatamab, combined with standard chemotherapy works better than the current standard treatment (trastuzumab plus chemotherapy) for people with advanced HER2-positive breast cancer that has worsened after a specific pr…

This study observes how well a CBD medication works for people with severe epilepsy syndromes (Lennox-Gastaut, Dravet, or Tuberous Sclerosis Complex) in real-world settings. About 100 children and adults who are already prescribed this CBD treatment by their doctor will be follow…

This study is testing an experimental oral medication called ONC206 for people with advanced pheochromocytoma or paraganglioma, rare tumors that often don't respond to standard treatments. About 90 participants will take the drug in different doses to see if it shrinks tumors and…

This early-stage study is testing whether a cannabidiol (CBD) oral solution can help reduce focal-onset seizures in people aged 12-75 who are already taking seizure medications. Researchers will measure how much the CBD reduces seizure frequency compared to before treatment and c…

This study is testing a drug called lurbinectedin in children and young adults whose Ewing sarcoma has come back or hasn't responded to other treatments. The first part aims to find a safe dose, and the second part will see how well the drug works to control the cancer. About 60 …

This is the first study in people testing an experimental pill called ONC206 for adults with recurrent brain tumors that have few treatment options. The main goal is to find the highest safe dose and understand the side effects. Researchers will enroll about 102 patients to test …

This study is testing an experimental drug called zanidatamab for people with advanced cancers that have a specific marker called HER2 and have stopped responding to prior treatments. It will enroll about 200 adults with various cancers including breast, lung, stomach, and ovaria…

This early-stage study is testing a new drug called JZP815 in people with advanced or metastatic solid tumors that have specific genetic changes in the MAPK pathway. The main goals are to find a safe dose, understand how the drug works in the body, and look for early signs that i…

This is the first study in people to test a new drug called JZP898. Researchers want to see if it is safe and tolerable when given alone and when combined with an existing immunotherapy drug (pembrolizumab) for adults with advanced or metastatic solid tumors. The main goals are t…

This study is testing whether adding a new targeted drug called zanidatamab to standard chemotherapy works better for people with advanced HER2-positive bile duct cancer. Researchers will compare the combination treatment against standard chemotherapy alone in 286 participants. T…

This early-stage study is testing a new drug called JZP441 to see if it can help adults with narcolepsy type 1 stay awake during the day. It will involve a small group of 8 participants to check how safe the drug is, how well it works, and how the body processes it. The main goal…

This study aims to understand the safety of the epilepsy medication Epidiolex during pregnancy. Researchers will follow about 50 women who took the drug while pregnant and monitor their babies' health for the first year of life. The goal is to collect information on birth outcome…