Georgetown University

This study tests whether a telehealth program can help cancer survivors prevent mouth sores, gum disease, and tooth decay. One hundred survivors who finished cancer treatment at least 6 months ago will either get the telehealth program or usual care. The goal is to see if the pro…

This early-phase study tests the safety of combining two drugs, NEROFE and doxorubicin, in people with advanced solid tumors that have a specific genetic change (KRAS mutation) and a protein called ST2. The main goal is to find the best dose and schedule. About 24 adults whose ca…

This study tests whether giving chemotherapy plus an immunotherapy drug (cemiplimab) before surgery can help people with stage 3 lung cancer that has spread to certain lymph nodes. About 21 adults will receive four cycles of the combination, then undergo surgery to remove the can…

This study compares two ways to help people quit smoking while they are getting lung cancer screening. About 1,188 adults who currently smoke and qualify for lung screening will be randomly assigned to one of two programs. The goal is to see which approach works better for helpin…

This study tests whether combining three drugs—daratumumab, nivolumab, and a KRAS vaccine—can shrink or control advanced pancreatic and lung cancers. About 54 adults whose cancer has worsened after standard treatment will receive the combination. The goal is to see if the treatme…

This study tests whether azeliragon, a drug that blocks a protein called RAGE, can reduce heart damage caused by chemotherapy in women with early-stage breast cancer. About 48 women will receive azeliragon alongside standard chemo to see if it is safe and helps prevent heart prob…

This study tests whether adding two immunotherapy drugs (durvalumab and tremelimumab) to standard chemotherapy is safe and effective for people with HIV who have advanced non-small cell lung cancer. About 18 participants will receive the treatment, and researchers will monitor si…

This study tests a chemotherapy drug called CPX-351 as a maintenance treatment for adults with acute myeloid leukemia (AML) who are in remission but cannot have a bone marrow transplant. The goal is to see if giving the drug for up to 6 cycles can keep the cancer from coming back…

This study looks at whether people with HPV-positive throat cancer who had surgery can safely receive a lower dose of radiation to a smaller area (just the neck, not the original tumor site). The goal is to keep cancer from coming back while possibly reducing side effects. About …

This study tests whether combining two drugs, pembrolizumab and lenvatinib, can shrink tumors in people with advanced cervical cancer that has stopped responding to initial treatment. The trial enrolls 35 adults whose cancer has spread or cannot be removed by surgery. The goal is…

This study tests a drug called sacituzumab govitecan in 18 adults with advanced thymoma or thymic carcinoma that has worsened after at least one prior treatment. Participants receive the drug intravenously weekly for two weeks, then a week off, repeating until the disease progres…

This study is for people with early-stage HPV-positive throat cancer. Standard treatment uses full-dose radiation plus chemotherapy, which can cause long-term side effects. The study tests whether giving only lower-dose radiation (without chemo) can keep the cancer from coming ba…

This study in Malawi will test new strategies to help people at high risk for HIV stay on their prevention medication, including a long-acting injectable drug. About 9,900 participants, including female sex workers and men who have sex with men, will receive either standard care …

This study tests whether an 8-week mindful self-compassion program works as well when delivered by video as it does in person. About 80 adults with anxiety disorders or major depression will take part. The goal is to see if online delivery can reduce symptoms and improve emotiona…

This study is testing whether an internet-based program called SHUTi can help Black/African American prostate cancer survivors with insomnia. About 40 participants will be randomly assigned to either the SHUTi program (which teaches sleep-improving techniques over 6 lessons) or a…

This study tests a website designed to help thyroid cancer patients manage symptoms after radioactive iodine (RAI) treatment. About 88 adults who had RAI in the last three years will use either the new website or a standard one for four weeks. Researchers will check if the tool i…

This study tests whether a home-based computer training program can improve vision in people who have lost part of their visual field due to stroke, traumatic brain injury, or brain tumor. Researchers will use brain scans to understand how the brain changes with training. The stu…

This study tests whether a special website (decision aid) helps people with intermediate-risk thyroid cancer make informed choices about radioactive iodine treatment. About 408 participants will be randomly assigned to use either the decision aid or a standard information site. R…

This study tests a decision support tool for Black and Latina women at high risk for breast cancer. 80 participants will either get standard care or extra help making informed choices about breast MRI screening. The goal is to see if the tool helps women make decisions that match…

This study aims to see if offering combined breast and colon cancer screening navigation works better than focusing on breast cancer alone. It also tests whether adding genetic education before a referral to genetic services improves uptake. About 820 Black and Hispanic women age…