Georgetown University

This study tests a combination of three drugs (nivolumab, ipilimumab, and cabozantinib) in 14 adults with advanced melanoma that cannot be surgically removed. Participants receive the triple therapy for 12 weeks, then switch to two drugs for up to 2 years. The goal is to see how …

This study tests a combination of three drugs (fluorouracil, leucovorin, and nanoliposomal irinotecan) in 48 adults with advanced bile duct or gallbladder cancer that has worsened after standard chemotherapy. The goal is to see if this new mix can stop the cancer from growing for…

This study tests a combination of two drugs, venetoclax and rituximab, in people whose chronic lymphocytic leukemia (CLL) has come back or stopped responding to other treatments. The goal is to see how well the combo shrinks or controls the cancer. About 25 adults with relapsed o…

This study tests a combination of three drugs (tiragolumab, atezolizumab, and bevacizumab) in people with advanced non-squamous lung cancer whose disease has worsened after previous treatments. The goal is to see if this combo can shrink tumors and control the cancer. About 29 ad…

This early-phase trial tests a two-step treatment for advanced breast cancer that cannot be cured with surgery or radiation. First, patients receive a drug called talazoparib alone, then both talazoparib and avelumab together. The main goal is to check safety and side effects, wh…

This study tests a technology-based motor rehabilitation program for people with Rett syndrome. The goal is to help them use their arms more purposefully while reducing repetitive hand movements (stereotypies). Over about 6 months, participants learn to separate their hands to st…

This study looks at whether a simple, home-based walking program can help improve blood sugar, cholesterol, and body measurements in people living with HIV who also have metabolic syndrome. About 50 participants will gradually increase their walking over six months. The main goal…

This study looks at whether a web-based educational program can help relatives of people with BRCA1 or BRCA2 mutations understand their genetic testing options. About 240 adults who are close relatives of someone with a BRCA mutation will take part. Participants will either use t…