Georgetown University

This study tests a combination of three drugs (nivolumab, ipilimumab, and cabozantinib) in people with advanced melanoma that cannot be removed by surgery. The goal is to see if this triple therapy can keep the cancer from growing for at least one year. Participants receive the d…

This study tests a combination of three drugs (tiragolumab, atezolizumab, and bevacizumab) in people with advanced non-squamous non-small cell lung cancer that has already been treated. The goal is to see if this combo can shrink tumors or slow the disease. About 29 adults will t…

This study tests a combination of two drugs (BXCL701 and pembrolizumab) in 22 people with advanced pancreatic cancer that has spread. The goal is to see if this treatment can stop the cancer from growing for at least 18 weeks. Participants must be willing to have two tumor biopsi…

This study tests an experimental drug called MGC018 in people with extensive-stage small-cell lung cancer that has returned or not responded to treatment. The main goal is to see if the drug can shrink tumors in at least 25% of participants. About 9 adults will receive the drug b…

This study aimed to see if the drug daratumumab could improve nerve damage (peripheral neuropathy) in people with a blood condition called MGUS. Participants would have received weekly injections for two months, then every other week for four more months. However, the trial was w…

This study tests whether combining venetoclax (a pill) with rituximab (an injection) can shrink or control chronic lymphocytic leukemia (CLL) that has come back or stopped responding to other treatments. About 25 adults with CLL will receive this combination. The goal is to see h…

This study tests a combination of three drugs (fluorouracil, leucovorin, and nanoliposomal irinotecan) in 48 adults with advanced bile duct or gallbladder cancer that has worsened after standard chemotherapy. The main goal is to see if the treatment can stop the cancer from growi…

This early-stage trial tests a two-step treatment for people with advanced breast cancer that cannot be cured by surgery or radiation. First, participants receive a drug called talazoparib alone, then both talazoparib and avelumab together. The main goal is to check safety and si…

This study tests a technology-based training program to help people with Rett syndrome use their arms more purposefully and reduce repetitive hand movements. Over about 6 months, 14 participants will play special games that reward keeping hands apart and reaching for targets. The…

This study looks at whether a simple, home-based walking program can help improve blood sugar, cholesterol, and body measurements in people living with HIV who also have metabolic syndrome. Researchers will enroll 50 adults (with and without HIV) and ask them to gradually increas…

This study looks at whether a web-based educational program can help relatives of people with BRCA mutations understand genetic testing and decide if they want it. About 240 adults who are close relatives of someone with a BRCA mutation will be randomly assigned to use the online…