Genentech, Inc.

This study tests an experimental drug called RO7446603, given alone or with existing medications (aflibercept or faricimab), for people with diabetic macular edema—a condition that causes vision loss due to diabetes. The trial has two parts: an early safety phase (Phase I) and a …

This early-phase trial tested a new drug called RO7496353 combined with an immunotherapy (atezolizumab) and sometimes chemotherapy in 102 people with advanced lung, stomach, or pancreatic cancer. The main goal was to check safety and side effects. Researchers also looked at how t…

This early-phase study tested a personalized cancer vaccine (RO7198457) in 273 patients with advanced solid tumors like melanoma, lung, and breast cancer. The vaccine was given alone or with an immunotherapy drug (atezolizumab) to see if it was safe and how the body responded. Th…

This phase 2 study tested the drug Xolair (omalizumab) in 11 people with peanut allergies who had already completed a previous trial. The goal was to see if the drug could reduce serious allergic reactions. Participants received regular injections of Xolair and reported any peanu…

This phase II trial tested a drug called huMAb OX40L in 29 adults with mild allergic asthma. The drug is an antibody designed to block a protein that triggers allergic reactions in the airways. Researchers measured whether it could prevent breathing problems caused by allergens, …

This Phase II trial tested the drug vismodegib in 104 people with advanced basal cell carcinoma, a type of skin cancer that had spread or could not be surgically removed. Participants took a daily capsule until their cancer worsened or side effects became too severe. The study me…

This study looked at the long-term safety of the cancer drug vismodegib in 19 patients with ovarian cancer, basal cell carcinoma, or metastatic colorectal cancer. All participants had previously taken vismodegib in an earlier Genentech trial and were expected to benefit from cont…

This phase 2 study tested whether adding tiragolumab to the standard immunotherapy atezolizumab helps people with advanced non-small cell lung cancer who have not had chemotherapy. 135 participants received either the combination or a placebo plus atezolizumab. The main goals wer…

This study tested a drug called astegolimab in over 1,300 people with COPD who have frequent flare-ups. The goal was to see if adding this drug to standard care could reduce the number of moderate to severe COPD attacks over a year. Participants were current or former smokers wit…

This early-phase trial tested a new drug called cevostamab in 355 people with multiple myeloma that had returned or stopped responding to other treatments. The main goal was to check the drug's safety and find the right dose. While it may help control the disease, it is not a cur…

This study looked at how well ocrelizumab works in Black and Hispanic patients with relapsing multiple sclerosis (MS). About 179 participants received the drug and were monitored for relapses, disability progression, and brain lesions over 48 weeks. The goal was to see if the tre…

This study tested whether adding a personalized cancer vaccine (RO7198457) to the immunotherapy drug pembrolizumab works better than pembrolizumab alone for people with advanced melanoma that hasn't been treated before. The trial involved 131 participants and measured how long th…

This early-phase study tested an experimental drug called GDC-1971 combined with either osimertinib (for lung cancer) or cetuximab (for colorectal cancer) in 10 people with advanced cancers that had spread. The main goal was to check safety and find the right dose. Researchers al…

This study tests a drug called mosunetuzumab, given alone or with another drug (atezolizumab), in people with B-cell non-Hodgkin lymphoma or chronic lymphocytic leukemia that has come back or not responded to treatment. The goal is to find the best dose and check safety and effec…

This phase 2 trial tested an investigational drug called KPL-716 (vixarelimab) in 240 adults with prurigo nodularis, a skin condition causing intense itching and hard nodules. The study compared the drug to a placebo to see if it could reduce itch severity over several weeks. The…

This study tested an experimental drug called GDC-6599 in 49 adults with chronic cough that persists despite treatment for asthma, COPD, or for unknown reasons. Participants took the drug or a placebo for two weeks, then switched. The goal was to see if the drug reduces cough fre…

This study tested how food and a common stomach-acid drug (rabeprazole) affect the amount of an experimental medicine called ZN-A-1041 in the blood. Twenty-four healthy adults took the drug under different conditions to measure absorption. The goal was to learn how to best take t…

This study looked at how the drug divarasib is processed in the bodies of 31 people with different levels of liver function, from healthy to severely impaired. Participants received a single dose, and researchers measured drug levels in the blood over time. The goal was to unders…

This early-stage study looked at how well two tablet versions of the experimental drug ZN-A-1041 are absorbed compared to a capsule form. It involved 18 healthy adults and also planned to check if food or a stomach-acid drug changes absorption, though that part was canceled. The …

This study tested how well healthy adults tolerate immunoglobulin G (IgG) injections given under the skin using different techniques. Researchers measured pain, injection-site reactions, and fluid leakage in 82 participants. The goal was to find the most comfortable and safe way …