Fondazione Irccs Istituto Nazionale Dei Tumori, Milano

This study tests a new combination of chemotherapy drugs (FLIRT) plus bevacizumab for people with a specific type of advanced colorectal cancer that has not been treated yet. The cancer must have a silenced MGMT gene and be microsatellite stable. The goal is to see if this target…

This study looks at whether women with certain aggressive breast cancers (HER2-positive or triple-negative) who have a complete response to chemotherapy can safely avoid surgery or radiation. About 152 women will be closely monitored instead of receiving these local treatments. T…

This study looks at men with metastatic hormone-sensitive prostate cancer that has spread to a few places. After 6 months of standard drug treatment, some men will also get local therapy (radiation or surgery) to see if it helps keep the cancer from growing longer. The goal is to…

This study looks at how the natural bacteria in your mouth might influence how well radiation therapy works for head and neck cancer. Researchers will collect saliva samples from 100 patients before, during, and after treatment to see if certain bacteria help control tumors or re…

This study looks at the immune system of people with desmoid tumors, a rare growth that is not cancer but can cause pain. Researchers will collect blood and tumor samples from 200 patients to find markers that might show if the tumor will shrink, stay the same, or grow. No new tr…

This study is building a large registry of up to 13,600 adults with rare head and neck cancers across Europe. Researchers will collect information from existing databases and doctors to track how these cancers behave, what treatments work best, and how patients fare over time. No…

This study is gathering information from 50 people with a rare cancer called epithelioid haemangioendothelioma (EHE). Researchers will look at medical history, symptoms, and blood samples to find biomarkers and create lab-grown tumor models. The goal is to better understand the d…

This observational study aims to see if a blood test can identify the same biological subtypes of HPV-negative head and neck cancer that are currently only found by analyzing tumor tissue. About 300 adults with advanced but curable cancer will give blood samples before and after …

This study creates a registry to collect information from 100 adults newly diagnosed with epithelioid hemangioendothelioma (EHE), an ultra-rare sarcoma. Researchers will track patients over time to understand how the disease progresses, what treatments are used, and what factors …

This study aims to create a more accurate way to predict duodenal cancer in people with familial adenomatous polyposis (FAP), a genetic condition that raises cancer risk. Researchers will analyze endoscopy images from 300 participants to build and test two risk models. The goal i…

This study looks at a rare head and neck cancer called adenoid cystic carcinoma (ACC) that has spread to other parts of the body. Researchers want to understand why some people's cancer grows slowly while others' grows quickly. They will study tumor samples and take blood tests o…