Fondazione Irccs Istituto Nazionale Dei Tumori, Milano

This early-phase trial is testing a combination of five chemotherapy drugs (FLIRT plus bevacizumab) as a first treatment for people with a specific type of metastatic colorectal cancer that has spread. The cancer must have a silenced MGMT gene and be microsatellite stable. The st…

This phase 2 trial is testing whether women with HER2-positive or triple-negative breast cancer who have a complete response to chemotherapy can safely skip surgery or radiation. The study will enroll 152 women and monitor them for cancer recurrence, distant spread, or death. The…

This Italian study is testing whether adding local treatment (radiotherapy or surgery) to standard apalutamide and hormone therapy can delay cancer progression in men with metastatic hormone-sensitive prostate cancer. About 566 participants will first receive drug therapy for 6 m…

This study looks at whether a simple blood test can give the same information about a tumor's biology as testing the tumor tissue itself. Researchers will collect blood samples from 300 adults with HPV-negative head and neck cancer before and after standard treatment. They will c…

This large observational registry aims to collect data from over 13,000 adults across Europe with rare head and neck cancers, including cancers of the nasopharynx, nasal cavity, salivary glands, and middle ear. Researchers will track patient outcomes like survival, treatment resp…

This study creates a registry to collect information from 100 adults newly diagnosed with epithelioid hemangioendothelioma (EHE), an ultra-rare sarcoma. Researchers will track patients over time to understand how the disease progresses, what factors affect outcomes, and which tre…

This observational study aims to understand why metastatic adenoid cystic carcinoma (ACC) of the head and neck behaves differently in different people. Researchers will analyze stored tumor tissue and blood samples from 114 adults to see if certain biological types (ACC-I or ACC-…

This study is for people with a rare cancer called epithelioid haemangioendothelioma (EHE). Researchers will collect medical information, blood samples, and tumor tissue to look for natural substances (biomarkers) that may help predict how the disease behaves. They will also crea…

This study looks at the immune system of 200 people with desmoid tumors, either under observation or receiving treatment. Researchers will analyze blood and tumor samples to find markers that may predict whether the tumor shrinks, stays stable, or grows. The goal is to better und…

This study looks at how the natural bacteria in your mouth might influence the effectiveness of radiation therapy for head and neck cancer. Researchers will collect saliva samples from 100 patients before, during, and after treatment to analyze the bacteria and viruses present. T…

This study aims to create a more accurate way to predict duodenal cancer risk in people with familial adenomatous polyposis (FAP), a genetic condition that greatly increases the chance of developing this cancer. Researchers will analyze endoscopy images from 300 participants to d…