Fondazione Irccs Istituto Nazionale Dei Tumori, Milano

This study tests a new combination of chemotherapy drugs (FLIRT) plus bevacizumab for people with a specific genetic type of metastatic colorectal cancer that has not been treated yet. The goal is to see if the treatment is safe and effective at delaying cancer growth. About 27 p…

This study is for women with HER2-positive or triple-negative breast cancer whose tumors completely disappear after chemotherapy. It tests whether it is safe to skip surgery or radiation and just monitor closely. About 152 women will take part to see if this approach works as wel…

This study is for men with metastatic hormone-sensitive prostate cancer that has spread to a limited number of sites. Participants first receive standard drug therapy (apalutamide plus hormone therapy) for 6 months, then are randomly assigned to either continue drug therapy alone…

This study looks at the immune system of 200 people with desmoid tumors, a rare type of growth. Researchers want to find out why some tumors shrink or stay stable without treatment. They will test blood and tumor samples to look for immune markers and DNA clues. No new treatment …

This study looks at how the natural bacteria in your mouth might influence how well radiation therapy works for head and neck cancer. Researchers will collect saliva samples from 100 patients before, during, and after treatment to see if certain bacteria help control tumors or re…

This observational study aims to see if a blood test can identify the same biological tumor types as tissue analysis in people with HPV-negative head and neck cancer. About 300 adults with locally advanced, curable cancer will give blood samples before and after treatment. Resear…

This study is for people with a rare cancer called epithelioid haemangioendothelioma (EHE). Researchers will collect medical information, blood samples, and tumor samples to learn more about the disease and find natural substances that could act as biomarkers. They will also crea…

This study is creating a registry of 100 adults newly diagnosed with epithelioid hemangioendothelioma (EHE), a very rare type of sarcoma. Researchers will collect information over time to better understand how the disease behaves, what factors affect outcomes, and which treatment…

This study looks at why some people with a rare head and neck cancer called adenoid cystic carcinoma have slow-growing disease while others have faster-growing cancer. Researchers will study tumor samples and blood tests from 114 adults to see if different cancer types (ACC-I and…