Could some breast cancer patients avoid surgery? new trial explores the possibility
NCT ID NCT06938724
First seen Jun 25, 2026 · Last updated Jun 26, 2026 · Updated 1 time
Summary
This phase 2 trial is testing whether women with HER2-positive or triple-negative breast cancer who have a complete response to chemotherapy can safely skip surgery or radiation. The study will enroll 152 women and monitor them for cancer recurrence, distant spread, or death. The goal is to see if avoiding these local treatments is as safe as standard care for these highly selected patients.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Omission of surgery or radiotherapy
- What this could lead to
- If successful, this could show that some women with these breast cancer types can avoid surgery or radiation after a complete response to chemotherapy, reducing treatment burden.
- What could go wrong
- This is a small, early-phase trial with only 152 participants. It is not yet proven that skipping local therapies is safe, and there is a risk of cancer returning without these treatments.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for BREAST NEOPLASM MALIGNANT FEMALE are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Fondazione IRCCS Istituto Nazionale Tumori Milano
RECRUITINGMilan, 20133, Italy
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Exercise during chemo: a new weapon to preserve strength?
- Can a High-Fiber diet shield the gut during breast cancer therapy?
- Can a triple drug combo shrink HER2-Positive breast tumors before surgery?
- Can an extra radiation dose keep HER2+ breast cancer at bay?
- Can mapping tumor DNA unlock personalized breast cancer care?
- Can a drug cocktail cure metastatic breast cancer? a trial aims to find out