Fondazione Irccs Ca' Granda, Ospedale Maggiore Policlinico

This study aims to find better ways to diagnose a brain condition called idiopathic normal pressure hydrocephalus (iNPH), which causes walking, thinking, and bladder problems in older adults. Researchers will combine memory tests, walking exams, brain scans, and spinal fluid anal…

This study is testing if eye drops made from umbilical cord blood plasma work better than standard artificial tears for people with moderate to severe dry eye. It will involve 100 adults whose eyes are severely irritated and damaged from dry eye disease. Researchers will compare …

This study aims to understand the genetic causes of unexplained adult cholestatic liver disease, where bile flow is impaired. Researchers will use whole-genome sequencing on 60 adults with unexplained liver test abnormalities to identify genetic variants. The goal is to improve d…

This study aims to better understand how a common genetic variant contributes to the development of a serious form of fatty liver disease. Researchers will create 3D models, called 'assembloids,' from liver tissue donated by 60 participants. These lab-grown models will be used to…

This study aims to create a laboratory test that can detect harmful substances in the blood of people with a specific kidney disease called primary podocytopathy, which causes nephrotic syndrome. Researchers will compare blood and urine samples from 150 people—including patients …

This study aims to understand why some people with fatty liver disease develop liver cancer. Researchers will study 500 adults with fatty liver disease to see how specific genes and family history affect cancer risk. The goal is to create a tool to identify high-risk individuals …

This Italian study observes women with endometriosis who want to have children. Researchers will compare pregnancy rates and live births between those who received medication versus surgery for their endometriosis. The goal is to understand which treatment approach might lead to …

This study aims to understand the normal size of the abdominal aorta in women and identify female-specific risk factors for aortic diseases like aneurysms. Researchers will enroll 652 women aged 50 and older to collect ultrasound measurements of their aorta and gather health hist…

This study aims to understand why some people with fatty liver disease develop serious liver or heart complications while others do not. Researchers will follow 2,500 middle-aged blood donors who are overweight or have related health issues. They will use genetic tests, blood mar…

This study aims to understand why some people with fatty liver disease develop serious liver damage, like cirrhosis or cancer, while others do not. Researchers will analyze the complete DNA of 2880 participants, comparing people with advanced disease to those with only risk facto…

This study aims to understand the genetic factors behind a rare and serious liver disease called primary sclerosing cholangitis (PSC). Researchers will create advanced 3D cell models, called 'assemblyloids,' from 80 participants to see how specific gene changes might lead to the …

This study aims to develop a faster blood test that measures the immune system's response in people with chronic hepatitis B and D. Researchers will observe 300 patients over time to see how their immune cells relate to their disease status and treatment outcomes. The goal is to …

This study aims to understand how the body's immune system responds to Hepatitis D, a serious liver infection. Researchers will observe about 192 patients with chronic Hepatitis D, some of whom are receiving a treatment called bulevirtide. The main goal is to learn how immune cel…

This study aims to understand how von Willebrand disease (VWD) affects the body's blood vessel cells. Researchers will collect blood samples from 48 people—some with VWD, some with a related acquired condition, and some healthy volunteers—to grow and compare their cells in the la…

This study aims to understand how a person's genes and their alcohol consumption interact to increase the risk of developing liver cancer. Researchers will analyze genetic data from 1,000 people with liver disease to identify specific genetic markers. The goal is to build a bette…