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Miniature Nerve-Muscle models may reveal why some myasthenia gravis patients Don't improve

NCT ID NCT07717281

Recruiting now Knowledge-focused Sponsor: Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico Source: ClinicalTrials.gov ↗

First seen Jul 21, 2026 · Last updated Jul 22, 2026 · Updated 1 time

Summary

This study investigates why about 10-15% of people with generalized myasthenia gravis (MG) do not respond to standard treatments. Researchers will take blood samples from 40 adults with MG and from healthy controls, then expose lab-grown human neuromuscular organoids to antibodies from these samples. By measuring changes in the organoids' electrical activity and structure, they aim to determine if irreversible damage at the nerve-muscle junction explains treatment resistance, and to identify blood biomarkers that could predict a refractory course.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to
If successful, this could identify blood tests that predict which patients will have refractory disease, and point toward new treatments that repair nerve-muscle damage.
What could go wrong
This is an early, observational study with only 40 participants. The organoid model may not fully replicate human disease, and findings may not translate to clinical practice.

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Conditions

The condition(s) this trial relates to.

myasthenia gravis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MYASTHENIA GRAVIS, GENERALIZED

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico

    RECRUITING

    Milan, 20122, Italy

    Contact Phone: •••-•••-•••• Email: •••••@•••••

    Contact

    Contact Email: •••••@•••••

    Contact

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