Children's Hospital Medical Center, Cincinnati

This study tests whether community health workers (CHWs) can help people with rheumatic heart disease (RHD) take their monthly antibiotic shots consistently. The trial will enroll about 308 participants in Brazil and Timor-Leste, including adults and children with RHD and their c…

This study tests whether text-message reminders and coaching can help 389 teens (ages 12-18) with moderate to severe asthma take their daily inhaled steroids as prescribed. Participants will be split into three groups: one gets a basic asthma app, another adds personalized text r…

This early study tests whether semaglutide, a drug already used for type 2 diabetes, can protect the body's insulin-producing cells in people with stage 1 type 1 diabetes. The goal is to see if it can delay or prevent the disease from progressing to the next stage. Fifteen adults…

This study tests whether an AI tool called RADAR can help nurses in low-resource settings detect rheumatic heart disease more accurately using echocardiography. The goal is to make screening easier to scale up worldwide. The trial will enroll 62 nurse screeners at participating f…

This study tests whether a tailored coaching program can help adolescents and young adults (ages 15-24) with cancer take their oral medications as prescribed. Participants will work with a coach over four sessions to identify and overcome barriers to adherence, using an electroni…

This study compares two medications, methylphenidate and guanfacine, to see which works better for treating ADHD in children ages 3 to 5. About 370 children with moderate to severe ADHD will take one of the drugs, and doctors will rate how much their symptoms improve. The goal is…

This study tests a cloud-based tool called ACT+ to help people in Uganda get follow-up care after a positive screening for rheumatic heart disease. Researchers will work with local providers to improve the tool and then see if it increases the number of people who complete a conf…

This study tests a virtual reality training program for pediatric doctors and nurses. The goal is to help them learn how to talk with parents about safely storing firearms at home. Thirty clinicians will complete the training and provide feedback on how useful and practical it is…