Children's Hospital Medical Center, Cincinnati

This study looked at how effective the Rotarix vaccine is at preventing severe rotavirus infections in children under 6 years old. Researchers enrolled 362 children with acute gastroenteritis at two U.S. hospitals, comparing those who tested positive for rotavirus (cases) with th…

This study tested whether losartan, a blood pressure medication, can reduce or stop scarring in the heart muscle of people with sickle cell disease. Fourteen participants aged 6 and older took losartan for 12 months. The goal was to see if the drug could improve heart health and …

This study tested whether N-acetylcysteine (NAC), an antioxidant drug, can improve motor skills and learning in children with neurofibromatosis type 1 (NF1). Twenty-five children aged 8 to 16 took NAC or a placebo for 8 weeks. The goal was to see if NAC is safe and helps with mov…

This study looked at ways to help children aged 5-20 with rheumatic heart disease take their regular antibiotics. Researchers compared having a case manager alone versus a case manager plus a peer support group. The goal was to see if the simpler approach works just as well to ke…

This completed Phase 1 study tested a special toothpaste containing tacrolimus in 7 patients with oral chronic graft vs. host disease (cGVHD) after a stem cell transplant. Participants used the toothpaste twice daily for three months alongside their usual medications. The goal wa…

This study tested the drug tofacitinib in 13 young adults aged 18 to 45 with moderate to severe lupus skin disease. The goal was to see if the drug is safe and can reduce skin symptoms. Participants took the drug for up to 76 weeks, and doctors measured how well it worked using a…

This early-stage study tested a mix of two drugs (pembrolizumab and decitabine) plus targeted radiation in 22 children and young adults whose solid tumors or lymphoma had returned or stopped responding to treatment. The main goals were to see if the combination was safe and toler…

This study tested a program called HALO for mothers who had weight-loss surgery and have school-aged children (ages 6-12) at risk for obesity. The program gave mothers education and parenting tips to encourage healthy eating and physical activity in their kids. Researchers measur…

This study tested whether a sugar called 2'-fucosyllactose (2FL) is safe and can help maintain gut health in 70 people receiving a bone marrow transplant. The goal was to see if it reduces infections and a complication called graft-versus-host disease. Participants took the suppl…

This study tested dupilumab, a drug that calms certain immune reactions, in 41 people aged 12-70 with eosinophilic gastritis, a condition where too many immune cells build up in the stomach lining. Participants received either dupilumab or a placebo injection every two weeks for …

This study tested a smartphone-based system to help children with epilepsy take their anti-seizure medication as prescribed. The system included educational information, automated reminders, and personalized feedback. The goal was to improve medication adherence, reduce seizures,…

This study tested a stepped-care program called TASC to help teenagers with moderate to severe asthma stick to their daily inhaler routine. 72 teens were randomly assigned to either the program or usual care. The program starts with simple reminders and steps up to more support i…

This study compares contrast-enhanced ultrasound to standard CT and MRI scans for detecting bowel inflammation in children aged 10–18 with Crohn's disease. Participants receive an ultrasound with a microbubble contrast agent alongside their regularly scheduled CT or MRI. The goal…

This study looked at better ways to screen teenagers (ages 15-21) for chlamydia and gonorrhea when they visit emergency departments. Researchers compared offering STI tests to everyone versus only to those with certain risk factors. The goal was to find the most effective and cos…

This study tested whether quercetin, a natural substance found in some foods, could help prevent a type of mouth cancer in people with Fanconi anemia, a rare genetic condition that raises cancer risk. 48 participants took quercetin to see if it reduced certain cell changes linked…

This study tested a web-based tool called MigraineManager for teens with migraines. The tool helps teens, their parents, and doctors track headaches and manage symptoms. The goal was to see if it could reduce how often headaches happen. 40 teens with frequent migraines took part.

This study tested whether N-acetylcysteine (NAC), an over-the-counter antioxidant, could improve learning and motor skills in children with neurofibromatosis type 1 (NF1). Five children aged 8 to 16 took NAC or a placebo to see if it helped with movement and attention problems. T…

This study tested whether giving children montelukast before and after tonsillectomy reduces their pain and need for strong painkillers. 116 kids aged 3-8 took part, receiving either montelukast or a placebo. Researchers measured pain scores and how often families contacted docto…

This study looked at two ways to numb the sciatic nerve for pain control after ACL surgery in 141 teenagers. One method used a single injection of anesthetic, while the other used a continuous drip through a small tube. Researchers measured pain scores, medication use, and knee m…

This study tested a virtual, group-based parenting program called 'Tuning in to Kids' for parents of children aged 3 to 6 with congenital heart disease. The goal was to see if the program was easy to use and helpful for parents. Thirty-nine parents took part in online surveys, we…

This small pilot study tested custom 3D-printed masks for children with sleep apnea who use CPAP machines. Researchers took 3D pictures of each child's face to create a perfectly fitted mask. The goal was to see if the custom mask was more comfortable and used more often over 6 m…

This completed study created a registry of 28 patients with TFE renal cell carcinoma, a rare kidney cancer. Researchers collected medical data, tumor samples, and images to better understand the disease. The goal is to use this information to guide future research and develop mor…

This study involved 8 children and teens with cystic fibrosis who had a history of MRSA infection and were already receiving the antibiotic ceftaroline. Researchers measured drug levels in the blood at different times to see how well the current dosing worked. The goal was to gat…

This pilot study tested whether personalized medication experiments could help teens with ADHD and their parents make better decisions about future medication use. Thirty-one parent-teen pairs (teens aged 11-15) completed a medication experiment chosen together. The goal was to s…

This study looked at over 5,000 critically ill children from hospitals worldwide to learn more about acute kidney injury (AKI). The goal was to better understand how common AKI is, what puts children at risk, and how to predict it using a tool called 'renal angina.' The study did…

This completed study tested whether a short, non-invasive brain stimulation technique called theta burst stimulation (iTBS) could improve brain circuits involved in tic control. Sixteen people with Tourette syndrome, aged 10 to 21, received either real or sham stimulation. The go…

This study tested a program called GET2HOME, which uses telehealth to support children with complex chronic conditions and their families after leaving the hospital. The goal was to see if the program reduces unplanned hospital visits and improves quality of life. Over 600 childr…

This study looked at a new method to find out if diuretics (water pills) help individual premature babies with a chronic lung condition called bronchopulmonary dysplasia (BPD). Researchers enrolled 19 very premature infants and used a special 'N-of-1' approach, where each baby wa…

This study tested a special MRI technique called Ultra Short Echo Time (UTE) to see if it can take clearer pictures of the lungs than traditional MRI. Researchers collected images and health information from people with and without lung disease to help doctors better understand l…

This study tested whether a remote simulation-based training program could help Emergency Medical Services (EMS) clinicians improve their skills in pediatric emergency procedures like placing a breathing tube or starting an IV. 133 EMS workers participated, submitting videos of t…

This study looked at how the timing of sleep affects what teenagers eat. Researchers wanted to understand why getting more sleep helps some teens eat less, but not others. They studied 190 healthy teens aged 14-18 to see if matching sleep to their natural body clock improves thei…

This pilot study tested a personalized program to help teens and young adults (ages 15-24) with cancer take their oral chemotherapy or preventive medications as prescribed. 70 participants were randomly assigned to either the tailored program or standard care. The main goal was t…

This study tested a new MRI technique using inhaled hyperpolarized xenon gas to detect early signs of bronchiolitis obliterans syndrome (BOS), a common form of chronic rejection after lung transplant. Only 3 participants were involved, and the goal was to see if the imaging could…