Children's Hospital Medical Center, Cincinnati

This study aimed to measure how well the Rotarix vaccine prevents severe rotavirus infections in young children. Researchers compared children hospitalized or visiting the emergency room with rotavirus (cases) to similar children without rotavirus (controls). They looked at vacci…

This study tested whether a personalized coaching program could help teenagers and young adults with cancer take their oral medications correctly. Researchers compared the coaching program to a simpler program that just sent weekly feedback. The main goal was to see if the coachi…

This study aimed to find the best dose of the antibiotic ceftaroline for children and teens with cystic fibrosis who have a history of a specific hard-to-treat lung infection (MRSA). Researchers measured how the drug moved through the bodies of 8 young patients to see if standard…

This study tested if a drug called tofacitinib, which is used for arthritis, could help control moderate to severe skin rashes caused by lupus. It involved 13 young adults and primarily aimed to see if the drug was safe and how it behaved in their bodies over 76 weeks. The resear…

This study tested whether a quick, non-invasive brain stimulation technique could improve the brain's ability to control unwanted movements in people with Tourette Syndrome. Researchers worked with 16 children and teens, using a special magnetic pulse on a specific brain area tho…

This study tested a smartphone-based program to help children with epilepsy take their medication more consistently. It involved 268 children, aged 2-12, who were newly diagnosed. The program provided families with education, digital reminders, and personalized feedback to help t…

This small, early-stage study tested a new combination of three treatments—an immunotherapy drug, a chemotherapy drug, and targeted radiation—in children and young adults (ages 1-40) whose cancers had returned or stopped responding to standard treatments. The main goals were to s…

This study tested a smartphone-based program designed to help teenagers with moderate-to-severe asthma remember to take their daily inhaler medication. 72 teens aged 12-18 were assigned to either use this new program or continue their usual care. The program used text reminders, …

This study tested whether a special telehealth support program could help children with complex chronic conditions avoid returning to the hospital after being discharged. Researchers worked with 638 children and their families to provide coordinated care through video calls and c…

This study tested if a special sugar called 2'-fucosyllactose (2FL), given as an oral supplement, could help protect the gut in children and young adults receiving a bone marrow transplant. The goal was to see if the supplement could reduce harmful gut bacteria, lower inflammatio…

This study tested whether dupilumab, an injectable medication, could reduce harmful inflammation in the stomachs of people with eosinophilic gastritis. Forty-one participants aged 12-70 received either the drug or a placebo injection every two weeks for 12 weeks. The main goal wa…

This study tested a new type of MRI scan using a special gas to see if it can detect early signs of a serious complication called BOS in people who have had a lung transplant. BOS is a form of chronic rejection that affects over half of transplant recipients who survive five year…

This study aimed to find the best and most affordable way to screen teenagers for gonorrhea and chlamydia when they visit a pediatric emergency room. Researchers tested two methods across a national network of hospitals: one that offered testing to all teens and another that targ…

This study tested whether the timing of extra sleep affects what teenagers eat. Researchers worked with 190 healthy teens, comparing 'Morning Larks' and 'Night Owls,' to see if aligning longer sleep with their natural body clock reduces calorie intake and unhealthy foods. The goa…

This study tested a family-focused program designed to prevent childhood obesity. It worked with mothers in the first year after weight loss surgery and their children aged 6-12 who were at risk for obesity. The program taught healthy eating and activity habits for the whole fami…

This small pilot study tested whether a custom-made, 3D-printed mask could improve comfort and use for children needing CPAP therapy for sleep apnea. Fifteen children used a mask created from a 3D scan of their face for about six months. Researchers measured how often the mask wa…

This study tested whether a virtual parenting program called 'Tuning in to Kids' is practical and helpful for parents of young children with congenital heart disease. The program taught parents skills to help their children understand and manage emotions through weekly online gro…

This small, early-stage study tested a new toothpaste containing the medication tacrolimus. It was given to a few children and young adults who developed painful mouth sores after a stem cell transplant, a condition called oral graft-versus-host disease. The goal was to see if ap…

This large international study aimed to better understand and predict acute kidney injury (AKI) in children who are critically ill. Researchers observed over 5,000 children in intensive care units worldwide to see if a scoring system called 'renal angina' and certain urine tests …

This small pilot study aimed to test a research method for a future, larger trial. It looked at whether a specific testing approach could identify which premature babies with a chronic lung disease respond to a common water pill (diuretic). The goal was to gather information to d…

This study tested a new MRI technique to take clearer pictures of lungs without using radiation. Researchers compared images from healthy people and those with lung diseases to understand differences. The goal was to develop better imaging methods that could eventually help docto…

This study tested a new way to train emergency medical workers on life-saving procedures for children. Instead of bringing in outside experts, local trainers used head-mounted cameras to record themselves practicing. Remote pediatric experts then watched the videos and gave feedb…