Children's Hospital Medical Center, Cincinnati

This study compares a new flexible white dental crown (BioFLX) to the standard stainless steel crown for treating cavities in baby molars. Researchers want to see if the white crown works just as well as the metal one in terms of gum health, plaque buildup, wear, and staying in p…

This Phase 3 trial will test whether children and teens with mild rheumatic heart disease (RHD) can safely stop taking long-term penicillin. About 922 participants aged 5-20 who have stable or normalized RHD after at least 2 years of antibiotics will be randomly assigned to eithe…

This trial investigates whether giving a personalized dose of alemtuzumab (a drug that calms the immune system) before a stem cell transplant can improve outcomes for people with non-malignant diseases. Researchers aim to find the right dose that balances effectiveness and safety…

This phase 2 trial tests whether specially trained donor immune cells, called CIML-NK cells, can be safely given to 20 children and young adults (ages 1-39) with relapsed or refractory neuroblastoma. The cells are made from a half-matched donor and infused alongside standard dinu…

This study looks at a program called ADUNU, which aims to find and treat people with rheumatic heart disease in two districts of Uganda. The program uses portable ultrasound to screen for the disease and a registry to keep patients on preventive medication. Researchers will check…

This study tests whether a computer program that calculates a personalized dose of infliximab based on blood tests can help children with Crohn's disease achieve deep remission better than standard dosing. About 180 children and young adults (ages 6–22) newly diagnosed with Crohn…

This early-stage study is testing whether quercetin, a natural antioxidant found in foods, is safe and can reduce inflammation in male patients with XIAP deficiency, a rare genetic immune disorder. Twelve participants will take oral quercetin daily. The main goals are to check fo…

This study compares two ways of dosing the drug mycophenolate mofetil (MMF) for children with lupus nephritis, a kidney disease caused by lupus. One method uses a standard dose based on body size, while the other adjusts the dose based on drug levels in the blood. The goal is to …

This study tests whether giving patients donor-derived immune cells (VSTs) on a regular schedule can prevent dangerous viral infections after a stem cell transplant. 180 participants will be randomly assigned to receive VSTs either on a fixed schedule or only when a virus is dete…

This study tests whether specially trained immune cells from a half-matched donor can safely treat acute myeloid leukemia (AML) that has come back or not responded to standard treatment. About 20 people aged 2 and older will receive an infusion of these cells. The main goal is to…

This study is for children, teens, and young adults (ages 1 to 39) with acute leukemia that has come back or not gotten better with standard treatments. Researchers are testing whether combining two drugs—venetoclax and Vyxeos—is safe and tolerable. The goal is to find the best d…

This early-phase trial tests whether a combination of three drugs—inotuzumab ozogamicin, venetoclax, and dexamethasone (IoVeX)—is safe for children and adults with relapsed B-cell acute lymphoblastic leukemia (B-ALL). About 28 participants will receive the drugs over one or two 2…

This study looks at whether increasing physical activity helps teens with obesity lower high blood fats and improve how well their blood vessels work. About 110 participants aged 10–20 who are already in a structured weight loss program will wear fitness trackers and have their b…

This study tests two online parenting programs for parents of children born very preterm (before 32 weeks). The goal is to see if these programs improve parenting skills, reduce child behavior problems, and lower parent stress. Ninety families will be randomly assigned to one of …

This early study tests whether giving a bone-strengthening drug called zoledronate soon after a stem cell transplant can safely prevent bone loss and fractures in children. Researchers will enroll 20 children aged 5 to 18 who are at high risk for bone problems. The goal is to see…

This early-stage study tests whether a drug called emapalumab can prevent the body from rejecting a stem cell transplant. The study will include 20 patients who are at high risk for rejection. Researchers will also study how the drug works in the body to improve future treatments…

This study aims to find effective treatments for people with cystic fibrosis who have rare gene mutations not covered by current drugs. Researchers will test FDA-approved CF drugs on nasal cells in the lab, then confirm the best option in a personalized N-of-1 trial. Up to 50 par…

This study tests whether using a violet light lamp at home can slow the progression of myopia (nearsightedness) in children. 72 kids aged 5 to 12 will use either a violet light lamp or a regular white light lamp for 12 months. Researchers will measure changes in eye length and vi…

This study tests a new treatment for hereditary pulmonary alveolar proteinosis (hPAP), a rare lung disease where breathing becomes difficult. The therapy involves taking a patient's own lung cells, adding a working gene, and putting them back into the lungs. Only 3 people will jo…

This study tests a drug called Zemaira in 15 adults with eosinophilic esophagitis, a condition where white blood cells build up in the esophagus, causing pain and trouble swallowing. Participants receive Zemaira infusions for 4 weeks to see if it reduces inflammation and improves…

This study tests whether specially grown immune cells from an unrelated donor can safely treat viral infections in people with weakened immune systems, such as after a stem cell transplant. About 750 participants will receive these cells and be monitored for side effects like inf…

This study tests whether specially grown donor immune cells (viral-specific T-cells) can safely treat viral infections that often occur after a stem cell transplant. These infections can be serious and sometimes don't respond to standard antiviral drugs. The approach aims to boos…

This study is testing whether a smartphone app called SMART-IBD can help teenagers with inflammatory bowel disease (IBD) remember to take their medications and manage their symptoms. About 70 teens aged 13-17 will either use the full app with reminders and challenges or just a si…

This study tests a stem cell transplant approach for people with Fanconi Anemia who don't have a perfectly matched donor. The goal is to see if using lower doses of chemotherapy before the transplant can reduce serious side effects. About 70 participants will receive a transplant…

This phase 2 trial tests whether abatacept (Orencia) can improve lung disease in people with common variable immunodeficiency (CVID). About 38 children and adults will receive either the drug or a placebo for 6 months. The main goal is to see if lung damage on CT scans shrinks by…

This phase 3 trial tests a procedure called FETO, where a balloon is placed in the windpipe of a fetus to help lungs grow. It is for pregnant women carrying a baby with severe congenital diaphragmatic hernia, a condition where the diaphragm has a hole and organs move into the che…

This phase 2 trial is testing the drug mirdametinib in 40 people aged 2 and older with Langerhans cell histiocytosis or similar disorders. The goal is to see if this oral medication works better and has fewer side effects than current treatments. Participants take the drug twice …

This study tests a personalized way to dose hydroxyurea for children with sickle cell anemia. Instead of using weight alone, doctors will measure how each child's body processes the drug to find the best dose. The goal is to see if this approach reduces damage to the brain, kidne…

This study is testing whether a special PET scan tracer called 18F-FAPI-74 can detect scarring (fibrosis) in the lungs of people with active tuberculosis. About 30 adults with confirmed TB will get the tracer and a whole-body PET/CT scan during and after treatment. The goal is to…

This study is testing a special MRI technique that uses inhaled xenon gas to create detailed images of lung function. Researchers want to see how well it works in healthy children and adults, as well as in people with various breathing problems. Participants will inhale the gas a…

This study tests a new way to take pictures of babies' lungs using MRI with a special inhaled gas (129Xe) instead of X-rays or CT scans, which use radiation. The goal is to safely see how well the lungs are working in infants with breathing problems. About 12 infants in the NICU …

This study is testing whether a shorter, abbreviated MRI scan (called MRE) works just as well as the standard, longer scan for detecting inflammation and damage in the bowel of people with Crohn's disease. Researchers will enroll 300 children and adults who already need an MRE as…

This study tests a 12-session virtual training program for foster and kinship caregivers of children aged 2 to 9. The program teaches positive parenting skills through group discussions, videos, and role play. Researchers want to see if it reduces caregiver stress and prevents ch…

This study tests whether adding a daily pill (amitriptyline) to online cognitive behavioral therapy (CBT) helps prevent migraines in children better than online therapy alone. About 400 kids with frequent migraines will be followed for months to see if headache days drop by half …

This study tests a web-based program called Epilepsy Journey, which includes online modules and telehealth sessions with a therapist, to help teens with epilepsy improve their executive functioning skills like planning, organization, and emotional control. 310 teens aged 13-17 wi…

This study is testing a nurse-led mind-body program to help children and teens with migraine have fewer headache days. The program combines different treatment parts, like relaxation and coping skills, to find the best mix. The study will include 260 participants aged 10-17 who h…

This pilot study tests whether quercetin, a natural antioxidant found in many plants, is safe for people with Dyskeratosis congenita or telomere biology disorders. Twelve participants will take quercetin for 24 weeks while researchers monitor side effects and how well people stic…

This study tests a program called SCThrive, which includes virtual group sessions and a mobile app, to help 260 teens and young adults (ages 13-21) with sickle cell disease take charge of their health. Participants will complete surveys before, after, and 3 months after the 8-wee…

This early-phase trial tests whether the drug romiplostim can prevent dangerously low platelet levels caused by chemotherapy in children and young adults with newly diagnosed Ewing sarcoma. About 26 participants will receive romiplostim alongside their standard chemotherapy to se…

This study looks at whether adding a therapy dog to a group behavioral program helps children with autism manage their emotions better. About 240 children with autism who have trouble controlling emotions will take part. The program teaches emotion regulation skills, and some chi…

This study is testing two group programs for autistic middle-schoolers who are fully included in regular classes. One program focuses on organization, planning, and study skills; the other on social skills. 224 teens and their parents will be randomly assigned to one of the two p…

This study tests a telehealth program called STRW-T that teaches daily living skills like laundry, cooking, and money management to autistic adolescents in their last two years of high school. The program involves 15 weekly group and one-on-one sessions via Zoom. Researchers will…

This study tests a computer-based training program called FOCAL+ for teens with ADHD aged 16-19 who have a driver's license. The training teaches them to limit how long they look away from the road while driving. Researchers will measure if the training reduces risky glances duri…

This study tests whether deep transcranial magnetic stimulation (dTMS) is safe and helpful for teens aged 14-18 who are hospitalized with major depression and suicidal thoughts. About 60 participants will receive either real or sham dTMS alongside their usual care. The goal is to…

This study tests an online program called Survivor's Journey+ for teens and young adults (ages 15-25) who survived a pediatric brain tumor. The program teaches problem-solving and coping skills through weekly online coaching. Researchers want to see if it improves quality of life…

This study compares two methods of delivering oxygen during sleep in children aged 5-17 with Down syndrome and moderate to severe obstructive sleep apnea. Ten participants will have two sleep studies—one with continuous oxygen flow and one with pulse flow from a portable concentr…

This study tests a remote program called Regulating Together (RT) for children aged 8-17 with Tuberous Sclerosis Complex (TSC) who struggle with emotional outbursts. The program uses cognitive behavioral therapy and mindfulness in small group sessions over 5 weeks. Researchers wa…

This study tests a motor training program called 'Let's Move' for infants aged 3-8 months who are at high risk for cerebral palsy. The program involves weekly sessions alternating between clinic visits and video telehealth at home for 16 weeks. Researchers want to see if the prog…

This study compares two pain management techniques—an erector spinae catheter and intercostal nerve cryoablation—for teens aged 12-21 undergoing the Nuss procedure for pectus excavatum. Researchers will measure how quickly patients meet physical therapy goals, their opioid use, a…

This study looks at whether home blood pressure readings can correctly identify different types of high blood pressure (like masked or white coat hypertension) in children aged 6 to 18. Researchers will compare home measurements to 24-hour ambulatory monitors in 52 kids referred …

This study follows 2,000 children who receive stem cell transplants to better understand and detect lung injuries that can occur after the procedure. Researchers will track participants for two years, collecting samples and health data to find ways to diagnose problems earlier. T…

This study looks at how the drug hydroxyurea affects women with sickle cell disease and their babies during pregnancy and breastfeeding. Researchers will review medical records from 200 women to measure drug exposure and compare health outcomes. The goal is to better understand t…

This research study is looking at people with inherited red blood cell disorders, such as hemolytic anemia, to better understand the genetic causes. Researchers will study blood samples from up to 400 participants to identify specific gene changes. The goal is to improve diagnosi…

This study aims to determine how common sickle cell trait and sickle cell disease are across Uganda by analyzing up to one million blood samples. Researchers want to create a detailed map of where the condition is most prevalent, which could help improve healthcare planning. The …

This study looks at how the brain's motor networks change over time in children with dystonia, a movement disorder. Researchers will use noninvasive tests like EEG and EMG to measure brain activity at rest and during simple tasks. Children with deep brain stimulation (DBS) will b…

This study is a registry for people with Congenital Dyserythropoietic Anemia (CDA), a rare blood disorder. Researchers will collect medical information and blood or bone marrow samples over many years to better understand how the disease progresses, its causes, and how it affects…

This study looks at whether sleep habits of 11-12 year olds affect their immune response to the meningococcal vaccine (MCV4). About 66 healthy teens will wear a sleep tracker and keep their normal sleep schedule for 5 weeks. Researchers will measure antibody levels after vaccinat…

This study uses brain scans (fMRI) and sensory tests to explore how different types of chronic pain affect the brains of children and teens aged 10-17. Researchers hope to find shared and unique brain patterns across conditions like migraines, fibromyalgia, and abdominal pain. Th…

This study looks at how the body processes venetoclax when the tablet is crushed and mixed into a liquid. It includes 30 children and young adults with blood cancers who already take venetoclax this way. The goal is to measure drug levels in the blood and spinal fluid to ensure t…

This study looks at 600 teens and young adults (ages 14-26) with conditions like juvenile arthritis, fibromyalgia, or past surgeries to understand why some develop long-lasting pain while others don't. Researchers will examine pain sensitivity, immune markers, and social factors …

This study creates a large collection of blood, tissue, and medical information from up to 5,000 people with or at risk for pediatric heart disease. Researchers will use these samples to better understand the disease and find new ways to diagnose or treat it in the future. Partic…

This study explores whether playing specially designed sounds through headphones can normalize brain activity in children aged 5-10 with Fragile X Syndrome or autism. The goal is to reduce sensory sensitivity and improve learning. Participants will listen to sounds while their br…

This study looks at whether eosinophilic gastritis, a rare stomach condition, causes problems with how the stomach moves food. Researchers will use a special scan after an oatmeal meal to check stomach emptying in 30 people. The goal is to better understand if these motility issu…

This study is building a large collection of blood samples and health information from 5,000 adults with congenital heart disease and related conditions. Researchers will use this data to better understand how these diseases work and what affects patient health. No treatments or …

This study looks at how babies and toddlers with Fragile X Syndrome perceive sounds and learn language. Researchers will use brain imaging, hearing tests, and behavioral assessments to track differences in sound processing. The goal is to better understand early signs of speech a…

This study is creating a registry for children and adults whose liver cancer (hepatoblastoma) has come back or not responded to treatment. Researchers will collect medical information, tumor samples, and scans from up to 500 participants to learn more about the disease. The goal …

This study creates a national registry for people with pulmonary alveolar proteinosis (PAP), a rare lung condition. Researchers will collect data and blood samples to improve diagnosis, understand how the disease progresses, and develop better ways to measure its severity. Up to …

This study looks at how the brain processes speech when there is background noise, in people with autism, Fragile X syndrome, and those without either condition. About 60 participants will complete hearing tests, questionnaires, and brain-recording tasks while listening to sounds…

This study is a registry that collects information from 200 people with hemophagocytic lymphohistiocytosis (HLH), a rare condition where the immune system becomes dangerously overactive. Researchers will track how quickly HLH is diagnosed, what treatments are used, and what compl…

The SAFE study is a long-term research project following 250 adolescents and young adults with sickle cell anemia. It aims to understand how the medicine hydroxyurea affects growth, puberty, and the ability to have children. Researchers will also compare pregnancy outcomes betwee…

This study looks at how a brain area called the pre-SMA affects impulse control in teens with ADHD. Researchers will use a non-invasive technique called TMS to stimulate this area and measure brain activity. The goal is to better understand ADHD, not to provide treatment. 40 teen…

This study looks at whether children with sickle cell disease (SCD) develop enough antibodies after getting the measles vaccine. Researchers will enroll 130 children aged 6 months to 6 years who are due for their measles shots. Blood samples will be taken a few weeks after each d…

This study looks at new ways to measure lung changes in people with cystic fibrosis (CF) aged 12 to 21. Researchers will use a special MRI with a breathable gas called Xenon, along with a lung function test called LCI, to see how stopping or restarting airway clearance treatment …

This study aims to create a computer tool that uses MRI scans to predict which surgery will work best for children with obstructive sleep apnea (OSA). About 120 children with persistent OSA after tonsil and adenoid removal will be enrolled. The tool simulates airflow in the airwa…

This study uses MRI scans to learn how lungs grow and develop in both full-term and extremely preterm babies, especially those with a breathing problem called bronchopulmonary dysplasia (BPD). Researchers want to better understand how prematurity affects lung structure and functi…

This study is collecting blood, tissue, and medical information from up to 1,000 people with RASopathies—a group of genetic conditions that affect development and raise cancer risk. Researchers will store these samples and data in a database for future studies. The goal is to lea…

This study creates a central registry and tissue bank for people with DIPG or DMG, rare and aggressive brain tumors. Researchers will collect medical information, scans, and tumor samples from up to 1,500 patients of any age. The goal is to understand the biology of these tumors …

This study follows 100 infants diagnosed with or at high risk for cerebral palsy from birth to age 2. Researchers will track changes in motor skills, speech, cognition, and more to understand how the condition naturally progresses. The goal is to gather knowledge that could impro…

This study aims to create a reliable urine test that can detect thebaine, a substance found in poppy seeds. Twenty healthy adults aged 18-65 will eat poppy seed products and provide urine samples over two days. The goal is to validate a laboratory method to measure thebaine level…

This study is looking at how eosinophils (a type of white blood cell) grow, move, and cause inflammation in people with eosinophilic gastrointestinal disease, other eosinophilic inflammatory conditions, or food allergies. Researchers will also study healthy volunteers and family …

This study is looking at people with eosinophilic gastrointestinal disorders, which cause inflammation in the gut. Researchers want to see if simple questionnaires can tell how well a patient is doing, compared to looking at tissue samples from endoscopies. The goal is to find be…

This study is testing a special type of MRI that uses hyperpolarized xenon gas to create detailed images of lung function. Researchers want to see how well this method works in 100 healthy adults. Participants will inhale the gas and hold their breath for up to 16 seconds during …