Children's Hospital Medical Center, Cincinnati

This study is testing if the drug abatacept can help control a serious lung scarring disease that occurs in people with Common Variable Immunodeficiency (CVID), a rare disorder where the immune system doesn't make enough antibodies. The trial will enroll about 38 adults and child…

This study is testing whether a smartphone app called SMART-IBD can help teenagers with inflammatory bowel disease (IBD) stick to their medication schedules and manage their symptoms better. Researchers will compare 35 teens using the app—which includes medication reminders, symp…

This is the first human trial of a new therapy for hereditary pulmonary alveolar proteinosis (hPAP), a rare lung disease. Researchers will take a patient's own bone marrow cells, correct a faulty gene in the lab, and then transplant these 'fixed' cells back into the lungs. The go…

This study aims to find the most effective way to prevent migraines in children and teens using telehealth. Researchers will compare cognitive behavioral therapy (CBT) delivered via video calls alone versus CBT combined with the medication amitriptyline. The trial involves 400 yo…

This study is testing if a drug called romiplostim can help prevent dangerously low platelet counts caused by chemotherapy in people with Ewing sarcoma. The goal is to see if this supportive care helps patients complete their scheduled chemotherapy cycles on time and safely. Rese…

This study is testing a modified stem cell transplant procedure for patients with Fanconi anemia who have developed severe blood problems like bone marrow failure or leukemia. The goal is to see if using lower doses of certain chemotherapy drugs and removing another medication ca…

This study is testing a fetal surgery called FETO to see if it helps babies with a severe form of congenital diaphragmatic hernia (CDH) survive and be healthier. It compares the surgery to standard prenatal care. The goal is to help babies with underdeveloped lungs and a liver in…

This study compares two ways of giving a medication called mycophenolate mofetil to children and young adults with lupus nephritis, a serious kidney complication of lupus. One group gets the standard dose based on body size, while the other gets a personalized dose adjusted based…

This study is testing if a telehealth program focused on daily living skills helps autistic high school students become more independent. Researchers will compare it to a different telehealth program focused on social skills. The goal is to see which approach better prepares teen…

This study is testing two different ways to deliver oxygen during sleep to children with moderate to severe obstructive sleep apnea, particularly those with Down syndrome. Researchers will compare continuous oxygen flow with pulse flow (which delivers oxygen only during breathing…

This early-stage study is testing whether combining two existing cancer drugs, venetoclax and Vyxeos, is safe for children and young adults whose acute leukemia has returned or hasn't responded to previous treatments. Researchers will give the drugs to a small group of patients t…

This study is testing whether a non-invasive brain stimulation treatment can help teens who are hospitalized for severe depression. Researchers will use a magnetic coil placed on the head to stimulate specific brain areas, aiming to reduce depression symptoms and suicidal thought…

This study is testing a new movement training program called 'Let's Move' for infants at high risk for developing cerebral palsy. Researchers want to see if this program, which uses a mix of clinic visits and video coaching at home, is practical and acceptable for families. They …

This study aims to find effective treatments for people with rare cystic fibrosis gene mutations. Researchers will test existing CF drugs on patients' own nasal cells in the lab, then conduct personalized trials to see if those drugs help improve breathing. The goal is to match i…

This study is testing whether a medication called Zemaira, given as a weekly infusion for four weeks, can help adults with eosinophilic esophagitis. Researchers want to see if the treatment reduces inflammation in the esophagus and improves symptoms. The study will also monitor f…

This study is testing a personalized way to determine the starting dose of hydroxyurea, a standard medication for sickle cell anemia, in young children. Instead of using only weight-based dosing, researchers will use blood tests to understand how each child's body processes the m…

This study is testing whether exposure to violet light can slow down the progression of nearsightedness in children. Researchers will compare special violet light lamps to regular white light lamps in 72 children aged 5 to 13 who already have nearsightedness. The goal is to see i…

This early study is testing whether a drug called emapalumab can prevent graft rejection in high-risk patients receiving stem cell transplants. Researchers believe blocking a specific immune signal (interferon gamma) might stop the body from rejecting the new cells. The trial wil…

This study is testing whether giving special virus-fighting cells from a donor on a regular schedule works better than waiting until a viral infection appears in patients who have received a stem cell transplant. Researchers want to see if this preventive approach reduces serious…

This study is testing whether losartan, a blood pressure medication, can reduce or stabilize heart scarring in people with sickle cell disease. Researchers will follow 24 patients aged 6 and older for one year to see if the drug is safe and effective. The goal is to prevent heart…

This study is testing a new treatment for acute myeloid leukemia (AML) that has come back or hasn't responded to standard chemotherapy. Doctors take immune cells (called natural killer cells) from a partially matched family donor, boost them in the lab to create a 'memory-like' s…

This is a small, early-stage study to see if quercetin, a natural antioxidant found in foods, is safe and tolerable for boys with a rare genetic immune disorder called XIAP deficiency. The disorder causes severe, life-threatening inflammation. Researchers want to find out if quer…

This early-stage trial is testing whether a combination of three drugs—Inotuzumab Ozogamicin, Venetoclax, and Dexamethasone (called IoVeX)—is safe and tolerable for children and young adults (ages 1-39) whose B-cell acute lymphoblastic leukemia (B-ALL) has returned after prior tr…

This study is testing whether a non-invasive brain stimulation technique can help teens with ADHD improve their impulse control. Researchers will use magnetic pulses to stimulate a specific brain area involved in stopping unwanted actions. They will measure changes in brain activ…

This study is testing an oral drug called mirdametinib for people with rare histiocytic disorders like Langerhans Cell Histiocytosis (LCH). It aims to see if this targeted treatment works better and has fewer side effects than current chemotherapy, especially for patients whose d…

This study is testing whether virus-fighting white blood cells from healthy donors can be safely given to immunocompromised patients, including children, who have serious viral infections. The goal is to help control infections that are difficult to treat in people with weakened …

This study is looking at how adding exercise to a weight loss program affects the health of young people with obesity. It focuses on two things: the level of fats in their blood and how well their blood vessels work. About 110 participants, aged 10 to 20, will wear an activity tr…

This study is testing a new treatment for serious viral infections that can happen after a stem cell transplant. Researchers take virus-fighting white blood cells from the transplant donor, grow them in a lab, and give them to the patient if an infection occurs. The goal is to pr…

This study is testing a new computer tool designed to help doctors predict which surgery will work best for children with obstructive sleep apnea (OSA). Many children continue to have breathing problems during sleep even after surgery, so researchers are using special MRI scans t…

This study is testing a new type of MRI scan that uses a safe, inhaled xenon gas to create detailed pictures of how well lungs are working. Researchers want to see if this method works well for both healthy people and those with breathing problems, including children as young as …

This study is testing a new, safer MRI scan for babies in the NICU with lung problems. Instead of using X-rays or CT scans that expose infants to radiation, doctors use a special, safe xenon gas that the baby breathes in during the MRI to create detailed pictures of the lungs. Th…

This study is testing a new, shorter version of an MRI scan used to check the intestines in people with Crohn's disease. The goal is to see if a 15-minute scan that doesn't use injected contrast dye works as well as the standard 60-minute scan. Researchers will enroll 300 childre…

This study aims to develop and test a new urine screening method to detect thebaine, a substance found in poppy seeds. Researchers are recruiting 20 healthy adults to provide urine samples to validate the accuracy of this test. The goal is to create a reliable tool for detecting …

This study is testing if giving a bone-strengthening medication called zoledronate early can safely prevent bone disease and fractures in children who have had a stem cell transplant. It focuses on children aged 5 to 18 who are at high risk for bone problems. The goal is to see i…

This study is testing a new, more affordable virtual reality (VR) version of a driving safety program for teens with ADHD. The goal is to train teens to keep their eyes on the road and avoid dangerous, long glances away while driving. Researchers will compare the new VR training …

This study is testing whether a special group training program for foster and kinship caregivers can prevent behavior problems in young children in their care. It will compare the training to the usual support caregivers receive. Researchers aim to see if the training helps careg…

This study compares two different methods for managing pain after surgery to correct sunken chest (pectus excavatum). Researchers want to see which approach helps teens recover faster, reduces the need for opioid painkillers, and causes fewer side effects like numbness. Participa…

This study is testing two online parenting programs designed to help parents of children born very prematurely. The goal is to improve parenting skills, reduce the child's challenging behaviors, and lower parent stress. Researchers are comparing a standard 7-session program to a …

This study is testing whether a remote group therapy program called 'Regulating Together' can help children and teens with Tuberous Sclerosis Complex (TSC) better manage emotional outbursts and difficult behaviors. The program involves 5 weeks of online group sessions for kids an…

This study is testing whether adding therapy dogs to a group treatment program helps children with autism spectrum disorder manage emotional outbursts better than the same program without dogs. Researchers will compare two versions of the 'Regulating Together' program—one with do…

This study is testing an online program called Survivors Journey Plus (SJ+) that teaches problem-solving and coping skills to teens and young adults who survived pediatric brain tumors, along with their caregivers. Researchers want to see if this family-centered online coaching h…

This study is testing a mind-body skills program delivered by nurses to help children and teens (ages 10-17) with migraines reduce their headache days. Researchers are comparing different versions of the program to find the most effective combination of coaching sessions, home pr…

This study aims to better understand how lungs grow and develop in premature babies, especially those with a breathing disorder called BPD. Researchers will use MRI scans (up to three times) on 160 babies in the NICU to take detailed pictures of their lungs and airways. The goal …

This study aims to understand how the brain processes speech in noisy environments, specifically in individuals with Autism Spectrum Disorder and Fragile X Syndrome. Researchers will measure brain activity in 60 participants aged 15-35 using a special cap while they listen to sou…

This study aims to gather detailed information and tissue samples from children whose liver cancer (hepatoblastoma) has come back or hasn't responded to treatment. By creating a central registry and sample bank, researchers hope to understand why these cancers are so difficult to…

This study aims to understand how brain networks change in children with dystonia, a movement disorder that causes involuntary muscle contractions. Researchers will measure brain and muscle activity in 75 children, including some with deep brain stimulation devices, to see how th…

This study aims to understand how cerebral palsy develops in babies during their first two years of life. Researchers will follow 100 infants who either have cerebral palsy or are at high risk for it, checking their motor skills, speech, thinking, and other development regularly.…

This study aims to understand how a cancer drug called venetoclax works in the body when it's given as a liquid made from crushed tablets. It will enroll up to 30 children and young adults with blood cancers who are already receiving this liquid form because they cannot swallow p…

This study aims to understand how and why certain white blood cells called eosinophils cause inflammation in conditions like food allergies and gastrointestinal diseases. It will enroll 5,000 people, including patients with these conditions, their family members, and healthy volu…

This study aims to understand how infants and toddlers with Fragile X Syndrome process sounds and develop language. Researchers will use brain scans, hearing tests, and language assessments to track 30 children (15 with FXS and 15 without) from 6 to 24 months old. The goal is to …

This study is building a large collection of blood and tissue samples from children with heart disease. Researchers will store these samples to help future studies understand the causes of heart problems and develop better treatments. The study is observational, meaning it collec…

This study aims to create a detailed registry of patients with Hemophagocytic Lymphohistiocytosis (HLH), a rare and serious immune system disorder. Researchers will collect information about how patients are diagnosed, what treatments they receive, and their long-term health outc…

This study is creating a large collection of blood samples and health information from adults with congenital heart disease and related conditions. Researchers will follow 5000 participants over time to gather data that will help future studies understand how these heart conditio…

This study is testing a new type of MRI scan that uses a safe, inhaled xenon gas to take detailed pictures of how the lungs work. Researchers want to see if this method provides better images than standard MRI scans. They are enrolling 100 healthy adults who can hold their breath…

This long-term study follows 250 young people with sickle cell anemia to understand how the medication hydroxyurea affects their growth, puberty, and ability to have children. Researchers will track participants over time, comparing those who take hydroxyurea to those who don't, …

This study aims to find out if children with sickle cell disease develop good protection after receiving their measles vaccines. Researchers will check blood samples from about 130 children before and after their routine measles shots to measure their immune response. The goal is…

This study aims to learn if new, sensitive MRI scans can detect lung changes in teens with cystic fibrosis when they temporarily stop and then restart their daily airway clearance therapy. Researchers want to see if these scans are better than standard breathing tests at spotting…

This study aims to find better ways to measure how patients with eosinophilic gastrointestinal disorders (EGIDs) are doing. It will follow 1350 children and adults over time during their normal doctor visits. Researchers will compare tissue samples from routine scopes with answer…

This study is creating a worldwide database and tissue bank for patients diagnosed with DIPG or DMG, which are rare and aggressive brain tumors primarily affecting children. Researchers are collecting medical records, scans, and tumor samples from up to 1,500 patients to better u…

This study aims to better understand a group of rare genetic conditions called RASopathies, which include Noonan Syndrome and Neurofibromatosis. Researchers will collect blood, tissue, and health information from up to 1,000 participants who have or are suspected of having one of…