Centre Hospitalier De L'université De Montréal (chum)

This study tests whether adding a high-dose stimulant medication and/or a reward-based program (contingency management) to standard care helps people reduce how often they use methamphetamine. About 440 adults with moderate to severe methamphetamine use disorder will be randomly …

This study looks at whether using a heart-lung machine (ECMO) routinely during lung transplants is better than using it only when necessary. About 218 adults getting a lung transplant will take part. The goal is to find out which approach reduces time in the ICU and improves reco…

This study looks at whether giving radiation to the chest after surgery and chemo-immunotherapy can help people with stage III non-small cell lung cancer who still have signs of cancer after treatment. About 118 adults will be randomly assigned to receive or not receive radiation…

This study tests whether adding targeted radiation to spots where prostate cancer has spread can help men whose cancer is already responding to hormone therapy. About 80 men with metastatic prostate cancer will be randomly assigned to get either standard care or standard care plu…

This study looks at whether giving a high-dose prescription stimulant (lisdexamfetamine) for 25 weeks is feasible and acceptable for people with moderate to severe methamphetamine use disorder. About 80 participants will receive either the drug or a placebo alongside their usual …

This study tests a method to make cornea grafts stronger before they are used as a support for the Boston keratoprosthesis type I, an artificial cornea. The goal is to see if strengthening the graft with a special light and vitamin treatment (crosslinking) can prevent the graft f…

This study is testing whether a special PET scan using F-choline can help doctors find and diagnose certain cancers and other medical conditions more accurately. Researchers will enroll 500 adults with known or suspected conditions where this scan might provide useful information…

This study tests a new method to find air leaks in the lungs during surgery. Doctors blow a visible glycerine smoke into the lungs, and the smoke escapes through any leaks, making them easy to spot. The goal is to reduce complications and hospital stays for 200 lung transplant pa…

This study tests a portable device that uses electrical signals to detect early fluid buildup in the lungs of heart failure patients. The goal is to see if it works as well as standard imaging methods like ultrasound. If successful, this device could help patients manage their co…

This study tests a new ultrasound method to better detect early-stage liver cancer, which standard ultrasound often misses. About 328 adults at risk for liver cancer will receive both standard and new ultrasound scans. The goal is to see if the new technique finds more tumors, es…

This study explores whether adding Acceptance and Commitment Therapy (ACT) to ketamine treatment is practical for 30 people who have both alcohol use disorder and depression that hasn't improved with standard medications. Participants will receive weekly ketamine infusions and AC…

This study compares three robotic-assisted surgery methods for removing lung tumors to see which causes the least chronic pain. About 120 adults having lung surgery will be randomly assigned to one of three techniques. The goal is to find a way to reduce nerve damage and long-ter…

This study looks at a procedure called EUS-guided celiac plexus neurolysis (EUS-CPN) to help manage pain from pancreatic cancer. Doctors usually inject a numbing drug (bupivacaine) before alcohol to prevent pain, but it's unclear if it helps or might even reduce the procedure's e…

This study is testing a mobile app designed to help adults who use cannabis for non-medical reasons adopt safer habits. About 110 participants in Quebec will use the app and report how often they use protective strategies, like avoiding risky situations. The goal is to see if the…

This study looks at better ways to detect and repair air leaks that can happen during lung surgery. Researchers will use a special bio-adhesive to seal leaks in donated human lungs that were not used for transplant. The goal is to reduce complications and shorten hospital stays f…

This study looks at whether cannabidiol (CBD) can reduce the mind-altering effects of THC, the main psychoactive ingredient in cannabis. Researchers will give 100 healthy, occasional cannabis users different combinations of CBD and THC and measure their experiences. The goal is t…

This study tests whether a diet low in methionine (an amino acid) can change gut bacteria and reduce inflammation in 40 healthy adults. Participants follow the special diet for several weeks, with some also taking methionine supplements or a placebo. Researchers will measure gut …

This study checks the safety of a radioactive substance called N-13 ammonia, made at the hospital's own lab, for use in heart scans. About 20,000 adults who need a heart scan will receive this substance and be watched for any side effects. The goal is to make sure the substance i…

This study uses donated human lungs to develop a standard method for a new freezing catheter that can take tissue samples (biopsy) and destroy abnormal tissue (ablation). Researchers will test different freezing times and temperatures to find the safest and most effective techniq…

This study tests a new device called STING-MARK that helps doctors mark the exact location of a tumor for image-guided treatments. Researchers will use donated organ samples (not live patients) to see if the marker is easy to place, stays in place, and shows up clearly on scans. …

This study looks at how many women who had high-risk pregnancies experience postpartum depression. Researchers will screen 100 patients using a standard questionnaire and a decision tool to see if this approach helps detect depression and guide women to the right care. The goal i…

This study tests whether a specific method of removing the breathing tube after abdominal surgery can prevent lung complications like collapsed lungs or pneumonia. It involves 270 adults at moderate to high risk for such problems. The goal is to find a better, evidence-based appr…

This study aims to understand how young adults aged 18-24 use cannabis in their daily lives. Researchers will follow 350 regular users over two years, collecting data through a mobile app about how often they use, what products they choose, and how much they consume. The goal is …

This study collects tears from 300 people with healthy eyes or with dry eye, eye infections, mucous membrane pemphigoid, or allergic conjunctivitis. Researchers will analyze the proteins and metabolites in the tears to create a unique 'fingerprint' for each condition. The goal is…