Ann & Robert H Lurie Children's Hospital Of Chicago

This early-phase trial tests a new vaccine (rHSC-DIPGVax) combined with two immunotherapy drugs (BALSTILIMAB and ZALIFRELIMAB) in children with diffuse intrinsic pontine glioma (DIPG) or diffuse midline glioma (DMG). The vaccine is designed to train the immune system to attack tu…

This study looks at whether adding a second ligament repair (ALL) to standard ACL surgery in children can prevent the new graft from tearing again. About 240 kids and teens (18 and under) who need ACL surgery will be randomly assigned to get either ACL repair alone or ACL plus AL…

This study tests whether a smartphone app and digital sensors, along with extra support from an asthma coordinator, can help families better manage their child's asthma. About 80 parent-child pairs will take part. The goal is to see if this approach is practical and helpful for c…

This study tests a special dye called Cytalux that makes cancer cells glow under near-infrared light. Surgeons use it during lung surgery to find and remove hard-to-see tumors in teens (ages 6-17) with bone cancer that has spread to the lungs. The goal is to see if the dye helps …

This study tests whether taking part in racial justice activism can prevent depression and lower stress-related health risks in Black and Latinx youth aged 15-20. Researchers will measure depressive symptoms and physical health markers like blood pressure and waist size over two …

This study looks at whether a 'watch and wait' approach to antibiotics can safely reduce unnecessary use in children with mild pneumonia. About 2,000 children will be randomly assigned to either get antibiotics right away or wait 72 hours to see if they improve on their own. The …

This study tests a program called H-HOPE for babies born with birth defects who need surgery soon after birth. The program includes special care and support to help with feeding, growth, and brain development, while also improving parents' mental health. About 40 babies and their…

This study looks at whether a Fitbit can help doctors catch infections early in children recovering from surgery for complicated appendicitis. About 500 kids aged 3-18 will wear a Fitbit after their operation. Researchers will analyze heart rate, activity, and sleep patterns to s…

This study looks at ways to support parents and guardians after their child (ages 10-17) visits the emergency room for suicidal thoughts or behaviors. Caregivers will be placed into one of three groups: usual care, follow-up phone calls, or automatic messages through the hospital…

This early-stage study looks at whether it's possible to run a larger trial of empagliflozin, a diabetes drug, in 40 children with chronic kidney disease. Participants are randomly assigned to take the drug or continue usual care for 3 months. Researchers will check if the drug i…

This study looks at why teens with obesity often regain weight after losing it. Researchers think hormones that control appetite might play a role. Participants aged 11-16 will replace meals with shakes and frozen dinners for a period, then be followed for up to 35 weeks to track…

This study looks at why Hispanic teenagers often wait longer for knee surgery after an injury, which can lead to long-term problems like arthritis. Researchers will interview athletes, families, and coaches to identify barriers such as insurance or language issues. Then they will…

This study collects tumor and normal tissue from children with cancer after they have passed away, with family consent. The tissue is used to create lab models and is shared with other researchers to better understand pediatric cancers. Up to 150 participants will be enrolled. Th…

This study is creating a registry of up to 500 people with eosinophilic gastrointestinal disorders (EGIDs), including eosinophilic esophagitis and colitis. Researchers will collect information from medical records, questionnaires, and tissue samples taken during routine procedure…