Ann & Robert H Lurie Children's Hospital Of Chicago

This study looks at whether a 'watch and wait' approach to giving antibiotics can safely reduce unnecessary use in children with mild pneumonia. About 2,000 children will be randomly assigned to either get antibiotics right away or wait 72 hours to see if they improve on their ow…

This early-phase trial tests a new vaccine (rHSC-DIPGVax) combined with two immunotherapy drugs (BALSTILIMAB and ZALIFRELIMAB) in children with diffuse intrinsic pontine glioma (DIPG) or diffuse midline glioma (DMG). The vaccine is designed to help the immune system recognize and…

This study tests whether taking part in racial justice activism can prevent depression and reduce stress in Black and Latinx teens and young adults (ages 15-20). Researchers will measure depressive symptoms and physical stress markers (like blood pressure and cholesterol) over 2 …

This study looks at whether a Fitbit can help doctors catch infections early in children who had surgery for a burst appendix. About 500 kids aged 3-18 will wear a Fitbit after surgery, and researchers will track their activity, heart rate, and sleep. The goal is to see if change…

This early-stage study looks at whether it's possible to run a larger trial of a drug called empagliflozin (a diabetes medicine) in 40 children with chronic kidney disease. The drug is given daily for 3 months to see if it improves blood pressure, urine markers, and heart functio…

This study is creating a registry of 500 people with eosinophilic gastrointestinal disorders (EGIDs) to learn more about symptoms, quality of life, and how the disease changes with treatment. Participants will fill out questionnaires and provide tissue samples during routine proc…