Adventhealth Translational Research Institute

This study looks for tiny particles in the blood, called exosomes, that might signal the start of type 1 diabetes. Researchers will compare children recently diagnosed with type 1 diabetes to healthy children, all aged 12 to 18. The goal is to find a better way to catch the disea…

This study is screening 115 underserved children and adults who are at risk for type 1 diabetes or celiac disease. Researchers will use blood tests to find early signs of these conditions, aiming to improve how we detect them. The goal is to catch these diseases sooner, especiall…

This study looks at why some people with type 2 diabetes do not get the usual health benefits from exercise. Researchers will measure how well cells produce energy before and after exercise. The goal is to find factors that make exercise less effective for certain individuals.

This study looks at how exercise training changes the way muscles and fat tissue handle insulin in people with type 2 diabetes. About 39 adults aged 30-65 who are sedentary and have type 2 diabetes will take part. Researchers will use PET scans and small tissue samples to measure…

This study looks at how aerobic and resistance exercise can change muscle cells in a lasting way, possibly improving metabolism and health. Researchers will take muscle samples from 179 adults before and after exercise training to see how cells adapt. The goal is to understand th…

This study looks at how a continuous 72-hour dose of glucagon (a hormone) affects energy expenditure in healthy, non-diabetic obese adults. About 30 participants will receive either glucagon or a placebo through an IV. The goal is to understand the body's energy use, not to treat…

This study looks at organ changes in people recovering from COVID-19, comparing those with and without type 2 diabetes. Researchers will use scans to measure organ size and volume. The goal is to learn more about how COVID-19 affects the body long-term in diabetic patients.

This early-phase study tests how well 20 healthy obese adults tolerate increasing doses of glucagon, a hormone that raises blood sugar. Researchers measure nausea levels to find the highest dose people can handle before feeling sick. The goal is simply to understand tolerability,…

This study looks at how exercise changes the signals muscles send to the rest of the body, especially those that help burn fat. Researchers will compare obese, lean, and athletic participants to find proteins or genetic codes released from muscle during exercise. The goal is to b…

This early-phase study is testing whether combining a low-carbohydrate diet with a diabetes drug (ertugliflozin) can safely produce moderate ketone levels in healthy adults. Nine participants will follow a gradually reducing carb diet while taking the drug, all under close superv…

This study aims to find new biological markers (biomarkers) for Adult Onset Autoimmune Diabetes (AOnAD) by analyzing blood samples from 25 adults with type 1 diabetes. Researchers will measure changes in specific microRNAs from tiny particles in the blood. No treatment is given; …

This study looks at how genes and fat cells differ in people with apple-shaped (belly fat) versus pear-shaped (hip and thigh fat) bodies. Researchers will use body scans and fat biopsies from 27 healthy adults to compare fat tissue at the molecular level. The goal is to better un…

This small pilot study is testing whether a 30-minute stationary bike ride on the same day as immunotherapy can help the treatment work better for people with skin cancers like melanoma. The study involves 12 patients and focuses on whether this exercise plan is practical and saf…