Adventhealth Translational Research Institute

This study aims to find new biomarkers in the blood that could help diagnose type 1 diabetes earlier and track its progression. Researchers will measure tiny particles from insulin-producing cells in teens recently diagnosed with T1D and compare them to healthy teens. The goal is…

This small pilot study tests whether a short exercise session on the same day as immunotherapy can help patients with skin cancers like melanoma. Twelve adults scheduled for their first immunotherapy will walk for 20-30 minutes before treatment. The goal is to see if this is feas…

This study looks at how exercise affects signals from muscles that help burn fat. Researchers will compare obese, lean, and athletic adults aged 18-40. Participants provide muscle and blood samples before and after exercise. The goal is to find proteins or genetic codes linked to…

This study looks at how aerobic and resistance exercise can leave a lasting "imprint" on muscle cells, helping them work better over time. Researchers will take small muscle samples from 179 adults before and after exercise training to study changes in cell metabolism and gene ac…

This study aims to understand how well people with obesity tolerate glucagon, a hormone that raises blood sugar. About 20 healthy obese adults will receive increasing doses of glucagon through an IV. Researchers will measure nausea using a questionnaire to find the highest dose t…

This study looks for early signs of type 1 diabetes and celiac disease in children and adults who are at higher risk but may not have easy access to healthcare. Researchers will test blood samples for specific antibodies that signal the start of these conditions. The goal is to f…

This study looks at why some people with type 2 diabetes don't get the full benefits of exercise. Researchers will measure how well cells produce energy before and after exercise training. The goal is to find factors that block exercise's positive effects, which could lead to bet…

This study looks at why some people store fat around their belly (apple shape) while others store it around their hips and thighs (pear shape). Researchers will take small fat samples from 27 healthy adults and study genetic markers to find clues. No treatment is given—the goal i…

This study looks at how a low-carb diet combined with an SGLT2 inhibitor (a diabetes drug) changes ketone levels in healthy adults. Nine volunteers aged 18-60 will follow different diets and take the drug to see if they can safely reach moderate ketosis. The goal is to understand…

This study looks at how COVID-19 may change organs like the heart, lungs, or kidneys in people who have diabetes and those who don't. Researchers will use scans to measure organ size and other changes in 35 adults who had COVID-19. The goal is to learn more about long-term effect…

This early-phase study looks at how a continuous 72-hour dose of glucagon (a hormone) affects energy expenditure in 30 healthy, non-diabetic obese adults. Participants receive either glucagon or a placebo via IV, and researchers measure changes in energy use and overall well-bein…

This study looks at how exercise training changes the way muscles and fat tissue respond to insulin in people with type 2 diabetes. Researchers will use PET scans and small tissue samples to measure glucose uptake and energy use. The goal is to better understand the benefits of e…

This study aims to find new biological markers (biomarkers) for Adult Onset Autoimmune Diabetes (AOnAD) by analyzing blood samples from 25 adults with type 1 diabetes. Researchers will measure changes in specific microRNAs in tiny particles called exosomes. The goal is to better …