Can a diet and drug combo safely boost ketones? small study aims to find out
NCT ID NCT05662865
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This early-phase study is testing whether combining a low-carbohydrate diet with a diabetes drug (ertugliflozin) can safely produce moderate ketone levels in healthy adults. Nine participants will follow a gradually reducing carb diet while taking the drug, all under close supervision. The goal is to understand how the body responds, not to treat any disease.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
ertugliflozin (SGLT2 inhibitor) and a low-carbohydrate diet
What this could lead to
If successful, this could help researchers understand how to safely achieve ketosis, potentially informing future treatments for metabolic conditions.
What could go wrong
This is a very small, early-phase study in healthy volunteers, so results may not apply to people with medical conditions. The diet and drug combination may cause side effects like dehydration or low blood sugar.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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AdventHealth Translational Research Institute
Orlando, Florida, 32804, United States