Can a diet and drug combo safely boost ketones? small study aims to find out
NCT ID NCT05662865
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This early-phase study is testing whether combining a low-carbohydrate diet with a diabetes drug (ertugliflozin) can safely produce moderate ketone levels in healthy adults. Nine participants will follow a gradually reducing carb diet while taking the drug, all under close supervision. The goal is to understand how the body responds, not to treat any disease.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- ertugliflozin (SGLT2 inhibitor) and a low-carbohydrate diet
- What this could lead to
- If successful, this could help researchers understand how to safely achieve ketosis, potentially informing future treatments for metabolic conditions.
- What could go wrong
- This is a very small, early-phase study in healthy volunteers, so results may not apply to people with medical conditions. The diet and drug combination may cause side effects like dehydration or low blood sugar.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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AdventHealth Translational Research Institute
Orlando, Florida, 32804, United States
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