TYMPANIC MEMBRANE PERFORATION

This early-phase trial tested a special insulin gel applied directly to the ear drum after surgery to repair a long-standing hole. Fifty adults with dry ear drum perforations received either the insulin gel or a plain foam control. The insulin group showed significantly better he…

This study compared two ways of preparing a tissue graft (temporalis fascia) for repairing holes in the eardrum caused by chronic ear infections. 92 adults aged 18–60 received either a wet or dry graft during tympanoplasty surgery. Researchers checked hearing improvement and graf…

This study tested a gel patch called Perf-Fix that doctors place over a chronic hole in the eardrum to help it close naturally. 71 people aged 5 and older with large, non-healing eardrum holes took part. The main goals were to see if the patch safely closes the hole and how easy …

This phase 2 trial tested whether a gel containing fibroblast growth factor-2 (FGF-2) can close long-standing holes in the ear drum. 52 adults with dry ear drum perforations lasting at least 6 months were randomly assigned to receive either the FGF-2 gel or a placebo, applied up …

This study tested a special graft made from pig tissue to close holes in the eardrum. Researchers followed 87 patients for 3 months after the graft was placed to see how many had complete healing. The goal was to find out if this material works well for repairing eardrum perforat…

This Phase 2 trial tested whether a gel containing human fibroblast growth factor-2 (FGF-2) can safely close chronic holes in the eardrum. Fifty-seven adults with dry eardrum perforations lasting over 3 months received either the FGF-2 gel or a placebo saline patch, with up to th…

This study compares two surgical techniques for repairing large eardrum holes caused by chronic ear infections. The interlay method places the graft between eardrum layers, while the underlay method places it beneath. Researchers measured hearing improvement in 60 adults to see w…

This study looked back at medical records of 980 children who had surgery to fix a hole in their eardrum. The goal was to see how often the eardrum healed closed and how well hearing improved after the operation. Researchers checked results 9 to 18 months after surgery.