Could a growth factor patch fix eardrums without surgery?
NCT ID NCT02307916
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This Phase 2 trial tested whether a gel containing human fibroblast growth factor-2 (FGF-2) can safely close chronic holes in the eardrum. Fifty-seven adults with dry eardrum perforations lasting over 3 months received either the FGF-2 gel or a placebo saline patch, with up to three treatments. The main goal was to see if the hole closed completely, with hearing tests as secondary measures.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Fibroblast Growth Factor-2 (FGF-2) applied on a gelatin foam patch with fibrin glue
- What this could lead to
- If it works, this could provide a simple, non-surgical way to close chronic eardrum holes, potentially restoring hearing and reducing infection risk.
- What could go wrong
- This is a small Phase 2 trial with only 57 people, so results may not apply to everyone. The treatment may not close the hole, and risks like infection or incomplete healing exist.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Massachusetts Eye and Ear
Boston, Massachusetts, 02114, United States
-
Wilford Hall, Lackland Airforce Base
Lackland City, Texas, 78236, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- Wet or dry? study tests best way to patch an eardrum
- Insulin gel mends ear drums faster in small trial
- Gel patch mends eardrums without surgery – new study shows promise
- Eardrum patch success in kids: 980 cases reviewed
- New Pig-Tissue patch shows promise for fixing eardrums