Could a gel patch fix a hole in your ear drum?

NCT ID NCT04960384

Completed Disease control Sponsor: NYU Langone Health Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This phase 2 trial tested whether a gel containing fibroblast growth factor-2 (FGF-2) can close long-standing holes in the ear drum. 52 adults with dry ear drum perforations lasting at least 6 months were randomly assigned to receive either the FGF-2 gel or a placebo, applied up to three times. The main goal was to see if the hole closed, measured by ear exams and photos.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: FGF-2 (fibroblast growth factor-2) applied on a gelatin sponge with fibrin glue
What this could lead to: If it works, this could provide a simple, non-surgical way to close chronic ear drum holes, potentially improving hearing and reducing infection risk.
What could go wrong: This is a small phase 2 trial with only 52 participants, so results may not apply to everyone. The treatment may not close the hole, and risks like infection or incomplete healing are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Tympanic Membrane Perforation

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

TYMPANIC MEMBRANE PERFORATION

Contacts and locations

Locations

NYU Langone Health

New York, New York, 10016, United States

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Other studies related to the condition(s) this trial covers.