TREATMENT-RESISTANT SCHIZOPHRENIA
Clinical trials for TREATMENT-RESISTANT SCHIZOPHRENIA explained in plain language.
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Could a common food preservative help treat Hard-to-Treat schizophrenia?
Disease control Recruiting nowThis study tests whether adding sodium benzoate—a substance that affects brain glutamate—to standard antipsychotic medication can improve symptoms and thinking in people with treatment-resistant schizophrenia. About 90 adults who have not responded well to at least two antipsycho…
Matched conditions: TREATMENT-RESISTANT SCHIZOPHRENIA
Phase: PHASE2 • Sponsor: National Cheng-Kung University Hospital • Aim: Disease control
Last updated Jun 27, 2026 14:00 UTC
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Magnetic seizures: a new hope for schizophrenia without the memory fog?
Disease control Recruiting nowThis study compares Magnetic Seizure Therapy (MST) to standard Electroconvulsive Therapy (ECT) in 80 people with treatment-resistant schizophrenia or schizoaffective disorder. MST uses magnetic pulses to trigger a controlled seizure, aiming to ease symptoms like hallucinations an…
Matched conditions: TREATMENT-RESISTANT SCHIZOPHRENIA
Phase: NA • Sponsor: Centre for Addiction and Mental Health • Aim: Disease control
Last updated Jun 27, 2026 09:02 UTC
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Shock therapy maintenance may keep schizophrenia at bay
Disease control Recruiting nowThis study looks at whether maintenance electroconvulsive therapy (ECT) can prevent relapse in people with schizophrenia that doesn't respond to the strongest medications. About 140 participants who improved after a course of ECT will either continue with maintenance ECT or recei…
Matched conditions: TREATMENT-RESISTANT SCHIZOPHRENIA
Phase: NA • Sponsor: Central Institute of Mental Health, Mannheim • Aim: Disease control
Last updated Jun 27, 2026 09:01 UTC
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New hope for Treatment-Resistant schizophrenia? phase 3 trial launches
Symptom relief Recruiting nowThis study tests an experimental drug called evenamide for people with schizophrenia that hasn't improved with standard antipsychotics. About 400 adults will receive either evenamide or a placebo added to their current medication for 12 weeks. The goal is to see if evenamide redu…
Matched conditions: TREATMENT-RESISTANT SCHIZOPHRENIA
Phase: PHASE3 • Sponsor: Newron Pharmaceuticals SPA • Aim: Symptom relief
Last updated Jun 27, 2026 13:02 UTC
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Old drug, new hope: could acetazolamide ease tough schizophrenia symptoms?
Symptom relief Recruiting nowThis study tests whether acetazolamide, a drug currently used for altitude sickness and glaucoma, can reduce positive symptoms (like hallucinations or delusions) in people with treatment-resistant schizophrenia. Sixty adults aged 18-55 who still have significant symptoms despite …
Matched conditions: TREATMENT-RESISTANT SCHIZOPHRENIA
Phase: PHASE1, PHASE2 • Sponsor: Vishwajit Nimgaonkar, MD PhD • Aim: Symptom relief
Last updated Jun 27, 2026 12:04 UTC
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New combo therapy aims to ease tough schizophrenia symptoms
Symptom relief Recruiting nowThis study tests whether adding a second drug that boosts NMDA receptors to a sigma-1 receptor agonist can better reduce schizophrenia symptoms than the sigma-1 drug alone. About 90 adults with schizophrenia who did not improve on at least two antipsychotics will take the combina…
Matched conditions: TREATMENT-RESISTANT SCHIZOPHRENIA
Phase: PHASE2 • Sponsor: China Medical University Hospital • Aim: Symptom relief
Last updated Jun 27, 2026 12:00 UTC
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Sleep therapy may ease psychosis in Treatment-Resistant schizophrenia
Symptom relief Recruiting nowThis study tests whether a type of talk therapy focused on sleep (CBT-I) can improve sleep, reduce psychotic symptoms, and enhance quality of life in people with treatment-resistant schizophrenia. About 60 adults with chronic psychosis and long-term sleep problems will receive ei…
Matched conditions: TREATMENT-RESISTANT SCHIZOPHRENIA
Phase: NA • Sponsor: Jimmi Nielsen • Aim: Symptom relief
Last updated Jun 27, 2026 08:12 UTC
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Brain training targets voices in schizophrenia
Symptom relief Recruiting nowThis study tests whether real-time fMRI neurofeedback can help people with schizophrenia who still hear voices despite medication. Participants learn to control their own brain activity while inside an MRI scanner, aiming to reduce the brain signals linked to auditory hallucinati…
Matched conditions: TREATMENT-RESISTANT SCHIZOPHRENIA
Phase: NA • Sponsor: Boston VA Research Institute, Inc. • Aim: Symptom relief
Last updated Jun 26, 2026 18:46 UTC