THROMBOSIS

This trial tests a device called the Symphony Thrombectomy System in people with acute pulmonary embolism, a condition where blood clots block arteries in the lungs. The device is designed to restore blood flow by suctioning out or breaking up the clots. The study will check how …

This trial tests whether giving the sedative dexmedetomidine during and after reconstructive microsurgery can help transplanted tissue (flaps) survive better in cancer patients. The study will compare flap health at 48 hours after surgery in patients receiving dexmedetomidine ver…

This study looked at 345 people with a severe stroke caused by a blockage in the basilar artery, a major blood vessel in the brain. It compared two treatments: giving a clot-busting drug followed by a procedure to remove the clot, versus doing the procedure alone. The goal was to…

This study tested a new, standardized process for providing assistive devices (like special tools) to help people put on and take off compression stockings. 220 adults who need these stockings long-term took part. The goal was to see if the new method improves how often people us…

This trial investigates whether a common genetic variation in the CES1 gene affects how the body processes two antiplatelet drugs, clopidogrel and ticagrelor. Healthy volunteers of Amish descent will take each drug for eight days in a crossover design, and researchers will measur…

This study looks at how well existing risk models predict dangerous blood clots in people with diffuse large B-cell lymphoma (DLBCL), a common type of blood cancer. Researchers will review medical records from over 1,500 patients across multiple hospitals to see which factors are…

This early-stage study tested a new drug called Vitalangio1 in 627 healthy adults aged 18–55 to see if it is safe and how the body processes it. Participants took either the drug or a placebo, and some took it with or without food to see how that affects absorption. The study doe…

This completed study tested whether sotagliflozin, a dual SGLT1/2 inhibitor, reduces blood clot formation better than empagliflozin, a standard SGLT2 inhibitor. Seventeen healthy volunteers took each drug for one month in a crossover design. Researchers measured clot size and pla…

This study looked at 100 people who recently had a major heart attack to better understand blood clots that can form in the heart's main pumping chamber. Using special PET/MR scans, researchers tracked clot activity in the heart and brain over several months. The goal was to lear…

This study tested whether using a softer, more flexible catheter material reduces irritation and failure of intravenous lines. Twenty-seven healthy adults each received two catheters (one standard, one more flexible) in opposite arms for up to 72 hours. Researchers measured cathe…

This study looked at 700 cancer patients to understand how often dangerous blood clots occur and how blood-thinning medications affect them. Researchers tracked patients over two years, analyzing blood samples and clotting events. The goal is to improve prevention and treatment o…