SURGERY COMPLICATIONS

This study tests whether giving intravenous (IV) iron before spinal fusion surgery can reduce the need for blood transfusions in teenagers with scoliosis who are also iron deficient. About 120 participants aged 10-19 will receive either IV iron or standard care. The goal is to se…

This study compares light versus deep general anesthesia in older adults (65+ or Indigenous 55+) having major surgery. The goal is to see if lighter anesthesia reduces delirium—a common, serious complication that can cause confusion and long-term brain decline. About 2,766 partic…

This study looks at 150 women having heart bypass surgery to see which type of graft—a vein from the leg or an artery from the arm—works better for the second most important heart artery. The goal is to find out which graft stays open longer and causes fewer problems. Participant…

This study tests whether taking CoQ10 and glutathione before and after heart surgery can prevent acute kidney injury. About 242 adults having elective bypass surgery will receive either the supplements or a placebo. The goal is to see if these mitochondrial-supporting nutrients r…

This study tests whether a home-based exercise program done before surgery can reduce disability and improve recovery. About 900 adults scheduled for major surgery will either follow the virtual training or receive usual care. The goal is to see if getting fitter before an operat…

This study tests whether fluvoxamine, an antidepressant, can reduce the risk of delirium (sudden confusion) in older adults after non-cardiac surgery. About 46 people having elective surgery will take the drug or a placebo. The goal is to see if this approach is practical for a l…

This study follows 15,000 adults aged 45 and older who are having same-day (noncardiac) surgery. The goal is to learn how often heart problems and other complications happen after these procedures, and to build a tool that helps doctors predict which patients are at higher risk. …

This study follows 150 adults for one year after ankle arthroscopy to track any complications that arise. Participants will have check-ups with their surgeon and physical therapist at 15 days, 3 months, 6 months, and 1 year after surgery. They will also fill out questionnaires an…

This study is testing whether wearable devices like Fitbits and Apple Watches can help predict and detect early complications after heart or lung surgery. Researchers will use machine learning to analyze data from 1,200 patients. The goal is to catch problems sooner and improve r…