STAGE IV PANCREATIC CANCER AJCC V8

This study is testing whether adding a new drug called pegcetacoplan to a standard chemotherapy regimen (mFOLFIRINOX) is safe and effective for people with metastatic pancreatic cancer. Pegcetacoplan aims to help the immune system fight the cancer and may also reduce the risk of …

This study is testing a procedure called HIPEC, which delivers heated chemotherapy directly into the abdomen, for people with pancreatic cancer that has spread to the abdominal lining. The goal is to see if this approach helps patients live longer and controls the cancer better t…

This study is testing whether a two-drug combination can help control advanced pancreatic cancer that has spread and cannot be surgically removed. The treatment is given as 'maintenance therapy' to patients whose cancer has stopped growing or shrunk after their initial chemothera…

This is the first human study of a new chemotherapy drug called TR-002. It aims to find the safest dose and understand side effects for people with advanced solid tumors, including pancreatic cancer, that have stopped responding to standard treatments. The study will enroll 52 pa…

This study is for people with advanced pancreatic cancer that has stopped responding to their first treatment. It is testing if adding a targeted drug called panitumumab to standard second-line chemotherapy helps patients live longer than chemotherapy alone. The trial is specific…

This study is testing a new four-drug combination for people with advanced pancreatic cancer that has spread or come back. It combines a new immunotherapy drug (BMS-986340) with an existing immunotherapy (nivolumab) and two standard chemotherapy drugs. The main goals are to see i…

This study is testing whether the drug talazoparib can help control advanced cancers in patients whose tumors have specific mutations in genes that help repair DNA damage. It is enrolling 36 adults with various advanced solid tumors (like breast, ovarian, prostate, pancreatic, an…

This study is testing the safety and effectiveness of a new two-drug combination for people with advanced solid tumors, including pancreatic cancer, that have spread or stopped responding to standard treatments. The trial aims to find the best dose and see if the drugs can help c…

This study is testing whether changing the timing of two standard chemotherapy drugs (gemcitabine and nab-paclitaxel) can improve treatment for pancreatic cancer that has spread. The goal is to see if this adjusted schedule helps shrink tumors better and is tolerable for patients…

This study is testing a new combination treatment for pancreatic cancer that cannot be removed by surgery or has spread. The approach uses a light-activated drug injected into the tumor to help the patient's own immune system, boosted by an immunotherapy drug (pembrolizumab), bet…

This study is testing an oral drug called pemigatinib for adults with advanced pancreatic cancer that has specific genetic changes (FGFR alterations). The goal is to see if blocking these abnormal genes can stop tumor growth and improve quality of life. The trial is conducted ful…

This early-stage trial is testing whether adding a new oral drug called CA-4948 to standard chemotherapy is safe and tolerable for people with advanced pancreatic cancer that has spread or cannot be removed by surgery. The main goal is to find the highest dose that patients can h…

This early-phase trial is testing a new treatment for advanced pancreatic cancer that has spread and carries a specific genetic change (KRAS G12D mutation). The treatment uses tiny natural packages from cells (called exosomes) to deliver a gene-silencing drug directly to the canc…

This study is testing whether delivering a higher, more focused dose of radiation can help people with advanced pancreatic cancer live longer. It's for patients whose cancer hasn't spread widely and who have already had 4-6 months of chemotherapy. Participants are randomly assign…

This study is testing if a simple, non-invasive therapy called ear acupressure can help improve appetite and prevent weight loss in people with certain advanced cancers. Researchers will recruit 66 patients with stomach, esophageal, or pancreatic cancer to see if applying small a…

This study aims to better understand cancer cachexia, the severe weight and muscle loss that often occurs with advanced cancers. Researchers will observe 800 patients with advanced colorectal, lung, or pancreatic cancer to identify different patterns or 'subtypes' of this conditi…

This early study aims to understand how six different investigational drugs affect the biology of pancreatic cancer tumors. It will enroll about 90 adults with various stages of pancreatic cancer. Participants take one of the drugs for about 10 days before a scheduled biopsy or s…

This study aims to learn more about the tiny blood vessels that feed solid tumors. Researchers will use a special microscope during a patient's standard cancer surgery to see these vessels in real time. The goal is to understand how tumor blood flow works and if it relates to how…

This early research study aims to understand how an experimental drug called OMO-103 affects pancreatic cancer cells in patients. Twelve adults with advanced pancreatic cancer will receive two infusions of the drug and undergo tumor biopsies to see if it changes the tumor's biolo…