STAGE IV PANCREATIC CANCER AJCC V8

This study tests two experimental drugs, ZEN003694 and entinostat, in people with advanced solid tumors that have stopped responding to standard treatments. The goal is to find the safest dose and see if the combination can shrink tumors. The trial includes up to 49 participants,…

This study tests whether adding the targeted drug panitumumab to standard chemotherapy helps people with a specific type of advanced pancreatic cancer (KRAS wild-type) live longer. About 94 adults whose cancer has spread or cannot be removed will receive either chemo alone or che…

This study tests a new drug called pegcetacoplan added to standard chemotherapy for people with metastatic pancreatic cancer. The goal is to see if the combination is safe and helps control the cancer longer. It also looks at whether pegcetacoplan can prevent dangerous blood clot…

This study tests a new way of giving two chemotherapy drugs (gemcitabine and nab-paclitaxel) to people with pancreatic cancer that has spread. The goal is to see if changing the timing of the infusion helps shrink tumors better. About 67 participants will be enrolled, and the stu…

This study tests a drug called pemigatinib in 40 adults with advanced or metastatic pancreatic cancer that has certain changes in the FGFR gene. The drug aims to block these abnormal genes and stop tumor growth. The study is done entirely through telemedicine, so participants can…

This early-phase study tests whether adding bosentan to standard chemotherapy can help control pancreatic cancer that cannot be removed by surgery. About 21 adults will receive the combination to find the safest dose and check for side effects. The goal is to slow or stop tumor g…

This study tests a new drug (BMS-986340) combined with immunotherapy (nivolumab) and two chemotherapy drugs (gemcitabine and nab-paclitaxel) in people with advanced pancreatic cancer that has spread or returned. The goal is to see if the combination is safe and shrinks tumors. Ab…

This study tests whether giving a higher dose of radiation can help people with locally advanced pancreatic cancer live longer. Participants must have already had 4-6 months of chemotherapy. The trial compares higher-dose radiation to standard care (more chemo, observation, or lo…

This early-stage study tests a new chemotherapy drug, TR-002, in about 52 people with advanced solid tumors that have stopped responding to standard treatments. The main goals are to find the safest dose and check for side effects. The study also looks at whether the drug can shr…

This early-phase trial tests whether adding leflunomide (an arthritis drug) to standard chemotherapy gemcitabine is safe and effective for people with advanced pancreatic cancer that cannot be removed by surgery. About 19 adults will receive the combination to find the best dose …

This study tests the drug talazoparib in adults with advanced solid tumors (like breast, prostate, ovarian, pancreatic, or stomach cancer) that have certain gene changes affecting DNA repair. The drug blocks a protein called PARP, which cancer cells need to fix their DNA, potenti…

This study tests a new combination for people with pancreatic cancer that cannot be surgically removed. It uses a light-activated drug (verteporfin) to make tumors more sensitive to immunotherapy (pembrolizumab) plus standard chemotherapy. The goal is to see if this approach shri…

This study is for people with pancreatic cancer that has spread to the lining of the abdomen. Doctors are testing a treatment called HIPEC, where heated chemotherapy drugs are placed directly into the belly during surgery. The goal is to see if this approach can help people live …

This early-phase study tests a new treatment called iExosomes for people with metastatic pancreatic cancer that has a specific mutation in the KRAS gene (G12D). The treatment uses tiny particles from stem cells to deliver a molecule that blocks the mutated gene's activity. The st…

This study tests whether a simple, non-invasive technique called auricular acupressure (using small pellets on the ear) can help improve appetite and prevent weight loss in people with advanced stomach, esophageal, or pancreatic cancer. About 66 participants will receive either a…

This study is for people with pancreatic cancer that can be removed by surgery or has spread. Researchers will give one of several drugs (cobimetinib, olaparib, onvansertib, azenosertib, AZD5305, or tremelimumab) for a short time before surgery or biopsy. By comparing tumor sampl…

This early phase 1 trial is studying how the drug OMO-103 affects pancreatic cancer cells in 12 patients with advanced or metastatic disease. The main goal is to see if the drug causes measurable changes in the tumor's biology by comparing tissue samples taken before and after tr…

This study uses a special microscope called intravital microscopy (IVM) to watch blood vessels inside solid tumors in real time during surgery. Researchers want to understand how these vessels work, which could help decide if a patient's tumor is likely to respond to certain trea…

This study looks at 800 people with advanced lung, pancreatic, or colorectal cancer to find different types of cancer-related weight and muscle loss (cachexia). Researchers will track symptoms, physical function, and blood markers over time. The goal is to identify distinct subty…