STAGE IV PANCREATIC CANCER AJCC V8

This study is for people with locally advanced pancreatic cancer that cannot be removed by surgery. After 4-6 months of chemotherapy, participants will either receive higher-dose radiation or standard care (more chemo, observation, or lower-dose radiation). The goal is to see if …

This early-phase study tests whether adding leflunomide (an arthritis drug) to standard chemotherapy (gemcitabine) is safe for people with advanced pancreatic cancer that cannot be removed by surgery. About 19 adults will take part to find the best dose and watch for side effects…

This early-phase study tests a new chemotherapy drug called TR-002 in about 52 adults with advanced solid tumors, including pancreatic cancer, that have not responded to standard treatments. The main goals are to find the safest dose and to understand side effects. Researchers wi…

This early-phase study tests a new treatment for people with advanced pancreatic cancer that has spread and has a specific mutation called KRAS G12D. The treatment uses tiny particles called exosomes to deliver a molecule that blocks the mutated gene. The goal is to find the best…

This study is testing whether changing the timing of two chemotherapy drugs, gemcitabine and nab-paclitaxel, can improve tumor shrinkage in people with pancreatic cancer that has spread to other organs. About 67 participants will receive the drugs on an optimized schedule. The go…

This study tests whether adding a targeted drug called panitumumab to standard chemotherapy helps people with a specific type of advanced pancreatic cancer (KRAS wild-type) live longer. About 94 adults whose cancer has spread or can't be removed will be randomly assigned to get c…

This study is testing a daily pill called talazoparib in people with advanced solid tumors (like breast, prostate, ovarian, or pancreatic cancer) that have specific DNA repair gene mutations. The drug works by blocking a protein that helps cancer cells fix their DNA, causing them…

This study tests a drug called pemigatinib in people with advanced or metastatic pancreatic cancer that has certain changes in the FGFR gene. The drug aims to block these abnormal genes and stop tumor growth. About 40 adults will take the pill at home and be monitored through tel…

This study tests a new combination for people with pancreatic cancer that cannot be surgically removed. It uses a light-activated drug (verteporfin) to make tumors more responsive to immunotherapy (pembrolizumab) plus standard chemotherapy. The goal is to see if this approach shr…

This early-phase trial tests whether adding bosentan to standard chemotherapy can help treat pancreatic cancer that cannot be removed by surgery. About 21 adults will take part to find the safest dose and check for side effects. The goal is to see if this combination can slow or …

This study tests whether adding a drug called pegcetacoplan to standard chemotherapy can help people with metastatic pancreatic cancer. The drug targets part of the immune system to slow tumor growth and may also prevent dangerous blood clots. About 35 adults with advanced pancre…

This study tests a new combination of drugs for people with advanced pancreatic cancer that has spread or come back. The treatment includes an experimental antibody (BMS-986340) plus immunotherapy and two chemotherapy drugs. The goal is to see if this mix is safe and shrinks tumo…

This study tests two experimental drugs, ZEN003694 and entinostat, in people with advanced solid tumors that have stopped responding to standard treatments, including pancreatic cancer. The goal is to find the safest dose and see if the combination can shrink tumors. About 49 par…

This study tests a treatment called HIPEC, which delivers heated chemotherapy directly into the abdomen during surgery. It is for people with pancreatic cancer that has spread to the lining of the belly. The goal is to see if this approach helps patients live longer and controls …

This study uses a special microscope to look at blood vessels inside solid tumors while patients are having surgery. The goal is to understand how these vessels work, which could help doctors decide if a patient's tumor is likely to respond to certain treatments. About 85 adults …

This study tracks 800 people with advanced lung, pancreatic, or colorectal cancer to understand why some lose weight and muscle (cachexia) and others don't. By identifying different patterns of weight loss, researchers hope to create better, more personalized treatments in the fu…

This early phase 1 trial is studying how the drug OMO-103 affects pancreatic cancer cells in 12 patients with advanced or metastatic pancreatic ductal adenocarcinoma. The main goal is to see if the drug changes the tumor's biology by analyzing tissue samples before and after trea…

This early-phase trial looks at how six different drugs affect pancreatic cancer tumors. Researchers will compare tumor samples taken before and after treatment to see if the drugs change the cancer's biology. The goal is to learn which drugs work best for different patients, hel…