STAGE IV PANCREATIC CANCER AJCC V8

This study compares a three-drug chemotherapy combination (nab-paclitaxel, gemcitabine, plus cisplatin) against the usual two-drug combination (nab-paclitaxel plus gemcitabine) in people with metastatic pancreatic cancer that has spread to other parts of the body. Only patients w…

This early-phase study tests a combination of two drugs, niraparib and dostarlimab, in 18 adults with BRCA-mutated breast, pancreas, or ovary cancer that has spread or cannot be surgically removed. Niraparib blocks a DNA repair protein in cancer cells, while dostarlimab helps the…

This early-phase trial tests the safety and best dose of a new drug (BAY 1895344) when given with standard chemotherapy (irinotecan or topotecan) for people with advanced solid tumors, especially small cell lung cancer, poorly differentiated neuroendocrine cancer, and pancreatic …

This study compares two chemotherapy combinations in older adults (age 70+) whose pancreatic cancer has spread. The goal is to see which treatment helps people live longer. About 176 participants will receive either gemcitabine with nab-paclitaxel or a combination of 5-FU, leucov…

This early-stage trial tests a new drug called CA-4948 combined with standard chemotherapy (gemcitabine and nab-paclitaxel) in people with pancreatic cancer that has spread or cannot be removed by surgery. The goal is to find the safest dose and see if the combination can shrink …

This early-phase study tests a new drug (M6620) combined with a standard chemotherapy (irinotecan) in adults with advanced solid tumors that have spread or can't be removed. The main goal is to find the safest dose and check for side effects. About 66 people with cancers like col…

This study tests whether a combination of two drugs, lenvatinib and pembrolizumab, can help keep advanced pancreatic cancer from getting worse. The trial involves 28 adults whose cancer has spread and cannot be surgically removed, and who have already responded to initial treatme…

This study tests two targeted drugs, palbociclib and binimetinib, in people with cancers that have RAS mutations, including certain ovarian and pancreatic cancers. The goal is to see if the combination can slow cancer growth better than one drug alone. About 199 adults will take …

This study tests whether adding the drug veliparib to standard chemotherapy (gemcitabine and cisplatin) works better than chemo alone for people with advanced pancreatic cancer who have BRCA or PALB2 gene mutations. About 83 participants will be enrolled. The goal is to see if th…

This study tests a new method called sonoporation, which uses ultrasound and tiny gas bubbles to help chemotherapy drugs get into cancer cells more effectively. The trial includes 120 adults with advanced or hard-to-remove pancreatic cancer who are already receiving standard chem…

This phase 2 trial tests whether adding pembrolizumab (an immunotherapy) to olaparib (a targeted therapy) works better than olaparib alone for controlling metastatic pancreatic cancer in people with inherited BRCA1 or BRCA2 mutations. About 88 participants will receive either the…

This early-stage trial tests two drugs together for people with advanced pancreatic cancer. One drug starves cancer cells by removing a key nutrient, while the other blocks a protein that helps them grow. The goal is to find the safest dose and see if the combination can control …

This early-phase study tests a new drug combination for people with advanced pancreatic cancer that has a specific marker (mesothelin). The treatment pairs a targeted chemotherapy with immunotherapy drugs and standard chemo to see if it's safe and what dose works best. About 74 a…

This early-stage trial aimed to test the safety of a new treatment called STIL101 for people with advanced pancreatic, colorectal, kidney, cervical cancer, or melanoma that has spread or cannot be removed. STIL101 is made from a patient's own immune cells taken from their tumor, …

This study tests whether a supervised, at-home resistance training program using a tablet is safe and helpful for people with advanced pancreatic cancer or those recovering from surgery. About 25 participants will do guided exercises during chemotherapy or after surgery. The goal…

This study tests whether using telemedicine and remote monitoring can help people with advanced digestive cancers manage chemotherapy side effects at home, reducing the need for emergency room visits and hospital stays. About 750 patients and their caregivers will receive enhance…