STAGE IV PANCREATIC CANCER AJCC V8
Clinical trials for STAGE IV PANCREATIC CANCER AJCC V8 explained in plain language.
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Experimental combo targets Hard-to-Treat cancers
Disease control OngoingThis early-stage trial tests a new drug (M6620) combined with a standard chemotherapy (irinotecan) in adults with advanced solid tumors that have spread or can't be removed by surgery. The main goal is to find the safest dose and check for side effects. About 66 people with cance…
Matched conditions: STAGE IV PANCREATIC CANCER AJCC V8
Phase: PHASE1 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated May 01, 2026 16:33 UTC
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Which chemo combo works best for older pancreatic cancer patients?
Disease control OngoingThis study compares two chemotherapy drug combinations in older adults (age 70+) whose pancreatic cancer has spread. The goal is to find which treatment helps them live longer. About 176 participants will receive either gemcitabine with nab-paclitaxel or a combination of 5-FU, le…
Matched conditions: STAGE IV PANCREATIC CANCER AJCC V8
Phase: PHASE2 • Sponsor: ECOG-ACRIN Cancer Research Group • Aim: Disease control
Last updated May 01, 2026 16:26 UTC
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New hope for tough pancreatic cancer: targeted drug combo trial launches
Disease control OngoingThis early-phase trial tests a new drug, anetumab ravtansine, combined with immunotherapy (nivolumab, ipilimumab) and chemotherapy (gemcitabine) in people with advanced pancreatic cancer that has a specific marker (mesothelin). The goal is to find the safest dose and see if the c…
Matched conditions: STAGE IV PANCREATIC CANCER AJCC V8
Phase: PHASE1 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated May 01, 2026 15:57 UTC
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New drug duo targets BRCA cancers in early trial
Disease control OngoingThis early-phase trial tests a combination of two drugs—niraparib and dostarlimab—in people with breast, pancreas, or ovarian cancers that have a BRCA gene mutation and have spread or can't be removed by surgery. Niraparib blocks a DNA repair process that cancer cells rely on, wh…
Matched conditions: STAGE IV PANCREATIC CANCER AJCC V8
Phase: PHASE1 • Sponsor: University of Washington • Aim: Disease control
Last updated Apr 30, 2026 15:52 UTC
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New combo therapy aims to stall pancreatic cancer growth
Disease control OngoingThis study tests whether a combination of lenvatinib and pembrolizumab can help control advanced pancreatic cancer that cannot be removed by surgery. About 28 adults whose cancer has not worsened after initial treatment will receive these drugs as maintenance therapy. The goal is…
Matched conditions: STAGE IV PANCREATIC CANCER AJCC V8
Phase: PHASE2 • Sponsor: City of Hope Medical Center • Aim: Disease control
Last updated Apr 30, 2026 15:51 UTC
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New combo therapy aims to stall pancreatic cancer in BRCA patients
Disease control OngoingThis study compares two treatments for metastatic pancreatic cancer in people with inherited BRCA1 or BRCA2 mutations. One group gets olaparib alone, the other gets olaparib plus pembrolizumab. The goal is to see if the combination helps keep the cancer from growing longer. About…
Matched conditions: STAGE IV PANCREATIC CANCER AJCC V8
Phase: PHASE2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Apr 30, 2026 15:50 UTC
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New immune cell therapy trial for advanced cancers withdrawn before start
Disease control TerminatedThis early-stage trial aimed to test the safety of a new treatment called STIL101 for people with advanced pancreatic, colorectal, kidney, cervical cancers, or melanoma. The treatment uses a patient's own immune cells taken from their tumor, grown in a lab, and then given back to…
Matched conditions: STAGE IV PANCREATIC CANCER AJCC V8
Phase: PHASE1 • Sponsor: City of Hope Medical Center • Aim: Disease control
Last updated Apr 29, 2026 15:05 UTC
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New drug cocktail aims to starve pancreatic tumors
Disease control OngoingThis early-stage trial tests a combination of two drugs—calaspargase and cobimetinib—in about 15 people with advanced pancreatic cancer that has spread. Calaspargase works by cutting off a key nutrient that cancer cells need to grow, while cobimetinib blocks a protein that helps …
Matched conditions: STAGE IV PANCREATIC CANCER AJCC V8
Phase: PHASE1 • Sponsor: OHSU Knight Cancer Institute • Aim: Disease control
Last updated Apr 29, 2026 15:03 UTC