STAGE IV BREAST CANCER AJCC V6 AND V7

This study is testing whether a newer hormone therapy drug called Z-Endoxifen works better than the standard drug tamoxifen for controlling advanced breast cancer. It involves 81 postmenopausal women whose cancer has spread, is fueled by estrogen, and has stopped responding to in…

This early-stage study is testing a new combination of two drugs, veliparib and carboplatin, for people with advanced HER2-negative breast cancer that has spread. The main goals are to find the safest and most effective dose and to understand the side effects. Researchers hope th…

This study is testing whether using two treatments together works better than one to control cancer that has spread to the spine and is at risk of pressing on the spinal cord. Doctors combine a heat treatment (thermal ablation) that destroys tumor cells with a very precise, high-…

This study is testing whether adding an immunotherapy drug (pembrolizumab) to two standard breast cancer drugs (letrozole and palbociclib) works better for controlling advanced breast cancer. It is for postmenopausal women whose cancer has spread and is fueled by estrogen. The go…

This early-stage trial aims to find safe doses and understand side effects of several drug combinations for patients with advanced cancers that haven't responded to standard treatments. The study involves 155 participants with various advanced or metastatic cancers and some rare …

This study is testing whether taking two oral drugs, cediranib and olaparib, together can help control advanced cancers that have spread or cannot be surgically removed. It is for adults with specific types of advanced lung, breast, or pancreatic cancer who have already tried at …

This early-stage trial is testing the safety and best doses of two different combinations of oral medications for people with recurrent endometrial, ovarian, or triple-negative breast cancer. The study combines an existing drug (olaparib) with one of two newer drugs (AZD2014 or A…

This early-stage trial is testing a combination of two drugs, cyclophosphamide and veliparib, for people with advanced breast cancer that has spread. The main goal is to find the safest and most effective dose of this drug pair. Researchers will also check if certain markers in a…

This early-stage study is testing a new hormone therapy drug called Z-Endoxifen for women with advanced breast cancer that has returned or spread. The main goals are to find the safest and most effective dose and to understand the drug's side effects. The study is for women whose…

This study is testing a special imaging scan to see if it can predict whether hormone therapy will work for patients with advanced breast cancer that has spread. The scan uses a radioactive form of estrogen to 'light up' cancer spots in the body. If successful, this scan could he…

This study is testing a special type of PET scan to see if it can measure how breast cancer tumors respond to hormone therapy. Researchers will scan patients before, during, and after treatment to see if changes in the scan images match how well the therapy is working. The goal i…