PREGNANCY, HIGH RISK

This study tests whether a continuous glucose monitor (CGM) paired with a coaching app helps pregnant women with type 2 diabetes achieve better blood sugar control compared to standard care. Participants use a Dexcom G7 CGM sensor and receive guidance through a mobile app and car…

This study compares two blood sugar targets for overweight or obese women with gestational diabetes. One group aims for stricter goals (fasting under 90 mg/dL, after meals under 120 mg/dL), while the other follows standard targets (fasting under 95 mg/dL, after meals under 140 mg…

This study compares two treatments for gestational diabetes: oral metformin pills and injectable insulin. Researchers want to see if metformin is as good as insulin at preventing problems for mothers and babies, like high birth weight or low blood sugar. About 1,500 pregnant wome…

This study looks at two ways of managing blood sugar during labor in pregnant women with type 1 diabetes. One group will follow a strict target (70-110 mg/dL), while the other will have a more relaxed target (70-140 mg/dL). The goal is to see if the relaxed approach is safe for n…

This study tests whether a 7-day course of three antibiotics (ceftriaxone, clarithromycin, metronidazole) can prolong pregnancy better than the current standard antibiotics in pregnant people hospitalized after their water breaks early (before 34 weeks). About 56 participants wil…

This study tests whether taking the blood thinner Lovenox three times a day works better than the standard twice-a-day schedule for pregnant women at high risk of blood clots. Pregnancy increases clot risk fivefold, and many women on the standard schedule don't get enough protect…

This study compares continuous glucose monitors (CGMs) to standard fingerstick testing in 180 pregnant women with type 2 diabetes. The goal is to see if CGMs reduce the number of large babies and improve blood sugar control. Participants will use either a CGM or traditional finge…

This study tests whether screening for gestational diabetes in the first trimester (instead of the usual third trimester) can detect the condition earlier in high-risk pregnancies. Researchers will use a combination of risk factors and blood markers to predict GDM. The goal is to…

This study looks at whether doing a diabetes test right after giving birth (instead of waiting 4-12 weeks) helps more women get screened for type 2 diabetes after having gestational diabetes. It also asks women about their views on heart-health programs after pregnancy. About 104…

This study tests whether a buprenorphine patch can reduce withdrawal symptoms when pregnant women with opioid use disorder start sublingual buprenorphine treatment. Forty participants will receive either a real patch or a sham bandage during the initial withdrawal period. Researc…

This study is following over 267,000 pregnant women in low- and middle-income countries to understand what factors lead to complications like stillbirth, maternal death, and preterm birth. Researchers will collect data on health risks and outcomes to create a large, harmonized da…