PREGNANCY COMPLICATIONS

This study tests whether using a continuous glucose monitor (CGM) that shows blood sugar levels on a smartphone app, along with a group chat for support, helps pregnant people keep healthy blood sugar levels. High blood sugar during pregnancy can cause problems for both mother an…

This study compares an automated insulin delivery system (CamAPS FX) to usual insulin methods in 305 women with type 1 diabetes who are planning pregnancy or are in early pregnancy. The goal is to see if the automated system helps keep blood sugar in a healthy range and improves …

This study looks at whether giving pregnant people at risk of preterm birth a single, half-sized dose of a steroid called Celestone works as well as the standard two-dose regimen to prevent serious health problems in newborns. About 3,250 participants will be randomly assigned to…

This study tests whether taking low-dose aspirin for six months after childbirth can help blood vessels heal and lower blood pressure in women who had preeclampsia. About 60 new mothers will receive either aspirin or a placebo. The goal is to see if this simple treatment can redu…

This study tests whether adding a specially trained doula to usual home blood pressure monitoring helps women with pregnancy-related high blood pressure achieve better blood pressure control one year after giving birth. About 454 women who had preeclampsia, eclampsia, or gestatio…

This study looks at whether it is possible and acceptable to start hepatitis C treatment during pregnancy for women who have used drugs in the past or currently. About 50 pregnant adults will take the medication glecaprevir-pibrentasvir and be followed for about a year. The goal …

This study tests whether adding a blood thinner (low molecular weight heparin) to daily low-dose aspirin can prevent preeclampsia in pregnant women at high risk. Preeclampsia is a serious condition causing high blood pressure and organ damage. The trial will enroll 100 women earl…

This study tests whether adding the drug certolizumab to standard treatment (blood thinners and aspirin) can prevent serious pregnancy complications like fetal death or early preterm delivery in pregnant women with antiphospholipid syndrome (APS) or lupus. About 55 high-risk wome…

This study tests whether providing extra money specifically for healthy foods during pregnancy can help prevent too much weight gain and related problems like high blood pressure and diabetes. About 1,440 pregnant women will either get standard care or extra funds (up to $3,000) …

This study tests a special balloon placed in the uterus after a C-section to prevent severe bleeding in women at high risk. About 70 participants will receive either standard care or standard care plus the balloon. The goal is to see if the balloon reduces blood loss and is safe …

This study tests whether a buprenorphine patch can reduce withdrawal symptoms in pregnant women with opioid use disorder when they start treatment. About 40 participants will receive either the patch or standard care during the required withdrawal period before taking sublingual …

This study tests whether a sedative called propofol or spinal pain relief works better when doctors try to turn a breech baby (feet-first) into a head-down position before birth. The goal is to help more women have a safer vaginal delivery and avoid a C-section. About 270 pregnan…

This pilot study tests a simple strength and resistance exercise program designed for high-risk pregnant women who are on bed rest in the hospital. The goal is to see if these gentle movements can improve their physical health, mood, sleep, and overall quality of life compared to…

This study follows 40 pregnant women with Lyme disease to see how the infection might affect their baby's development. Researchers will monitor pregnancies and check infant growth, thinking, and motor skills from birth to 18 months. The goal is to learn if Lyme exposure in the wo…

This study is a worldwide registry that will follow about 10 women with Fabry disease who took the medication pegunigalsidase alfa around the time of pregnancy or while breastfeeding. Researchers will track pregnancy outcomes and infant health for up to one year after birth. The …

This study follows 6,000 pregnant women in rural Pakistan to understand how high environmental temperatures impact pregnancy and birth outcomes. Researchers will track heat exposure, perform regular health checks, and monitor babies for up to a year after birth. The goal is to id…

This study looks at how things like pregnancy complications and birth outcomes affect the long-term health of mothers and children. Researchers will follow 24,000 mothers and their babies born at Boston Medical Center. The goal is to understand links between early life factors an…

This study looks at how pregnant women sleep, focusing on the positions they spend the most time in and how often they snore. About 500 women who are at least 28 weeks pregnant will use a sleep monitor at home. The goal is to learn more about sleep patterns during pregnancy and s…

This study tests two new ultrasound techniques to see if they can better detect placental problems in pregnancies with fetal growth restriction (FGR), where the baby is smaller than expected. Researchers will compare these scans in 60 pregnant women—some with healthy pregnancies …

This study follows 1000 couples going through IVF to see if the bacteria and chemicals in their bodies affect their chances of having a baby. Researchers will collect samples from both partners and track outcomes like pregnancy, miscarriage, and live birth. The goal is to learn w…

This study uses bedside ultrasound to measure muscle loss, fat changes, and fluid buildup in critically ill pregnant and gynecological patients. Researchers will track 121 women in the ICU to see if these body changes relate to serious outcomes like death, need for a breathing ma…

This study looks at how pregnant women at risk for preeclampsia process aspirin and how that relates to signs of metabolic problems. Researchers will measure aspirin breakdown products and other health markers in blood and urine. The goal is to better understand why some women st…

This study looks at whether routine blood sugar tests (like fasting glucose and HbA1c) can predict gestational diabetes in pregnant women who have had bariatric surgery and cannot tolerate the standard sugary drink test. Researchers will follow 84 women throughout pregnancy to se…

This study looks at whether women with gestational diabetes (GDM) also have sarcopenia, a condition of muscle loss and weakness usually seen in older adults. Researchers will test 200 pregnant women for muscle health and track pregnancy outcomes and thinking skills. The goal is t…

This study looks at how the body burns fat and uses insulin during pregnancy, and how that might affect the placenta. Researchers will follow 50 pregnant women at risk for preeclampsia or gestational diabetes. The goal is to better understand these conditions, not to test a new t…

This study follows pregnant women with a severe hemophilia A gene and their babies after birth. The goal is to learn why some mothers have heavy bleeding after delivery and why some children develop antibodies that block treatment. No new treatments are tested—just careful observ…

This study looks back at the pregnancy history of 50 women who were later diagnosed with lupus. The goal is to find out if certain pregnancy problems, like miscarriage or high blood pressure, happened more often before the lupus diagnosis. By understanding these patterns, doctors…

This study tests a tool called Periviable GOALS that helps parents and doctors make decisions together when a baby might be born extremely early (22-25 weeks). About 300 pregnant adults facing this situation will use the tool or receive standard care. The goal is to see if the to…

This study looks at how cells in the placenta die or clean themselves in women with pregnancy complications like preeclampsia or poor fetal growth. Researchers will examine placenta samples from 50 women after delivery to understand these processes better. The goal is to find new…