PHARMACOKINETICS

This study tested a new method of giving the antibiotic cefoxitin during colorectal surgery to prevent infections. Instead of the standard fixed dose, a pump was used to adjust the dose based on each patient's weight and kidney function. The trial included over 2,400 adults havin…

This study tested a computer program that helps doctors give the right dose of anti-rejection drugs to children who have had a kidney transplant. The program uses drug levels from blood tests to predict future exposure and adjust doses. 29 children participated, and the goal was …

This study tested the safety and how the body processes different doses of the drug noribogaine in 55 healthy adults. Participants received either the drug or a placebo, and researchers measured drug levels and side effects. The goal was to gather information, not to treat any di…

This study looked at how the drug sugammadex reverses vecuronium, a muscle relaxant used during laparoscopic (keyhole) surgery, in 48 obese patients. Researchers measured drug levels in the blood and how quickly muscle function returned. The goal was to better understand dosing f…

This study tested whether giving the drug pasireotide with a reusable pen works as well and is as safe as using a traditional syringe. Forty healthy adults aged 18 to 55 each received the drug by both methods on separate days. The goal was to see how the body absorbs the drug and…

This study looked at the safety and effects of kratom, a plant sometimes used for pain or opioid withdrawal, in 40 healthy adults who have used opioids recreationally but are not dependent. Participants received single increasing doses of kratom to see how the body processes it a…

This study looked at how the sedative ciprofol is processed in the blood of 36 people with moderate to severe hypoproteinemia (low protein levels). Researchers measured drug concentrations at different times after a single injection. The goal was to understand the drug's behavior…

This study looked at whether taking a new antibiotic (ceftibuten/VNRX-7145) with food changes how the body absorbs it. Twenty-four healthy adults took the drug once while fasting and once after a meal. The goal was to measure drug levels in the blood and check for side effects, n…