PHARMACOKINETICS

This early-phase study tested a new drug called boserolimab (MK-5890), either alone or combined with pembrolizumab, in 182 adults with advanced solid tumors (including lung and breast cancers). The main goal was to check safety and how the drug moves through the body. Participant…

This study tested a new method for giving the antibiotic cefoxitin during colorectal surgery to prevent infections. Instead of the standard one-size-fits-all dose, a computer-controlled pump delivered a personalized amount based on each patient's weight and kidney function. The t…

This study looked at how moderate liver problems affect the way the body handles a new experimental cancer medicine called sevabertinib. About 20 people—half with liver impairment and half healthy—took a single dose and had their blood levels measured over 5 days. The goal is to …

This early-phase study tested the safety and drug levels of BB-025, a potential reversal agent for the blood thinner BB-031, in 72 healthy adults aged 18–55. Participants received either BB-025 or a placebo, alone or after a dose of BB-031, and were monitored for 28 days. The goa…

This study tested whether a new rapid-acting insulin called I004 works the same as the approved insulin NovoLog. Sixty-nine healthy volunteers received a single dose of each insulin in a random order, and researchers measured how fast the insulin entered the blood and how well it…

This study tested whether a computer model can help doctors give the right dose of anti-rejection drugs to children after a kidney transplant. The model used drug levels from blood samples to predict future exposure and guide dosing. 29 children participated, and the goal was to …

This study looked at how the investigational drug MRX1 is processed by the body, its safety, and whether food changes its absorption. Twenty healthy adults took multiple doses of MRX1. The goal was to gather basic information, not to treat any disease.

This study looked at how sugammadex, a drug that reverses muscle relaxants, works in 48 patients having laparoscopic surgery. Researchers measured drug levels in the blood and how quickly patients recovered muscle function. The goal was to better understand the drug's effects, no…

This study tested if giving the drug pasireotide with a reusable pen works as well as using a traditional syringe. Forty healthy adults received single doses by both methods to compare drug levels and safety. The goal was to see if the pen is a reliable alternative for future pat…

This study looked at how safe kratom is and how the body processes it in healthy adults who have used opioids recreationally. 40 participants received single rising doses of kratom to monitor side effects and drug levels. The goal was to gather basic safety information, not to tr…

This study looked at how the sedative ciprofol is processed in 36 patients with moderate to severe hypoproteinemia (low blood protein). Researchers measured drug levels in the blood at different times after a single injection. The goal was to understand the drug's behavior, not t…

This study tested whether taking a new antibiotic (ceftibuten/VNRX-7145) with food changes how the body absorbs it. Twenty-four healthy adults took the drug once while fasting and once after a meal. Researchers measured drug levels in the blood to see if food affects absorption, …

This study tested the safety and how the body processes the drug noribogaine in 55 healthy adults aged 18 to 45. Participants received either the drug or a placebo, and researchers measured drug levels and side effects. The goal was to gather information, not to treat any disease…

This early-stage study tested a vaginal ring that releases two drugs (dapivirine and levonorgestrel) over 90 days in 40 healthy HIV-negative women. The goal was to measure how the body absorbs the drugs and check for safety and bleeding changes. It is a first step toward a produc…

This study looked at how two antibiotics, ceftibuten and ledaborbactam, move through the blood and lungs of 34 healthy adults aged 18 to 55. Participants took the drugs for several days and then had a bronchoscopy to collect lung fluid samples. The goal was to measure drug levels…

This study looked at how a single dose of the antibiotic combination ceftibuten/VNRX-7145 moves through the bodies of 32 adults with normal kidney function, mild to severe kidney problems, or end-stage kidney disease on dialysis. Researchers measured drug levels in the blood and …

This study tested a new slow-release form of pyridostigmine, a drug used for myasthenia gravis (a muscle weakness disease), against the regular tablet. Forty healthy adults took both versions to see how the drug is absorbed and if it's safe. The goal was to gather information, no…