PHARMACOKINETICS

This study tests an experimental pill called IPG7236 in people with advanced solid tumors that have spread or cannot be removed. The main goals are to check the drug's safety, find the best dose, and see if it can shrink tumors. About 196 adults will take the pill twice daily in …

This study checks if a new rapid-acting insulin (I004) works the same as the approved insulin NovoLog. About 60 healthy adults will receive a single dose of each insulin in a random order, and their blood sugar levels will be carefully controlled using a special clamp technique. …

This study looks at whether standard antibiotic doses are effective for children in the pediatric intensive care unit. Researchers will measure drug levels in the blood of 640 children to see if they reach the right targets to fight infections. The goal is to improve dosing guide…

This early-stage study tests whether a single inhaled dose of RCS-21 is safe and tolerable in 24 healthy volunteers aged 18 to 64. Participants receive either the drug or a placebo and are closely monitored for side effects and how the drug moves through the body. The study does …

This study looks at how antibiotics work in critically ill newborns, infants, and children who are on a life-support machine called ECMO. The goal is to see if current doses are enough to fight infections. Researchers will measure drug levels in the blood of 300 children to find …

This early-stage study tests a new antibiotic combination (ceftibuten-ledaborbactam) in about 46 healthy adults aged 18-55. The goal is to check safety and how the drug moves through the body, not to treat any disease. Results will help decide if further testing is possible.

This study tests how two different forms of the drug evolocumab (used to lower cholesterol) behave in the body. About 400 healthy adults aged 18 to 60 will receive a single dose of one version, and researchers will measure drug levels and side effects. The goal is to compare the …

This study tests how a new painkiller called PF614, given with another drug called nafamostat, moves through the body. 54 healthy adults aged 18-55 will receive a single dose and have their blood levels measured. The goal is to understand the drug's behavior, not to treat any con…

This study looks at how the antifungal medicine caspofungin behaves in children with severe infections in the intensive care unit. Researchers want to understand how conditions like liver problems or ECMO treatment affect the drug's levels in the body. The goal is to find the rig…

This study looks at how the body processes kava and kratom when taken together compared to taking each one alone. It involves 18 healthy adults who will try all three options in a random order. The goal is to understand any interactions, not to treat any disease.

This study looks at how smoking high-potency cannabis changes pain perception and feelings of a "good drug effect" in people who use it almost daily. Researchers will compare results when participants use cannabis as usual versus after a short period of not using it. The goal is …

This study looks at how antibiotics like amoxicillin and metronidazole work in the body when used with deep cleaning for severe gum disease. Researchers want to find the best dose and treatment length (3 vs 7 days) to kill harmful bacteria without overusing antibiotics. About 45 …