PELVIC ORGAN PROLAPSE

This study compares two types of vaginal surgery for pelvic organ prolapse (when organs like the bladder or uterus drop into the vagina). One method uses a synthetic mesh, the other uses standard sutures. About 358 women will be randomly assigned to one of the two surgeries and f…

This study tests whether adding a posterior repair (tightening the vaginal opening) to standard prolapse surgery helps prevent the prolapse from returning within a year. About 200 women with advanced prolapse are taking part. Half get the extra procedure, half do not, and researc…

This study compares two types of sling surgery for stress urinary incontinence (leaking urine with cough or sneeze) in women who are also having surgery for pelvic organ prolapse. One sling uses a single incision, the other uses two incisions. The trial will enroll 180 women and …

This study tests a new device called i-Stitch for repairing pelvic organ prolapse in 100 women. The device is used to attach the top of the vagina to a ligament in the pelvis. The goal is to see if it is safe and works well. Researchers will measure symptoms, quality of life, and…

This study tested a new laparoscopic surgery using an inverted T-shaped mesh to fix both the top and front of the vagina in women with advanced prolapse. Sixty-seven women who wanted to keep their uterus were followed for one year. The goal was to see if the new technique is safe…

This study tests a device called Materna Prep, which is used for 30-90 minutes during early labor to gently stretch the vaginal canal and pelvic floor. The goal is to reduce muscle injuries that can happen during vaginal birth. 420 first-time mothers or those with a prior early p…

This study compares cranberry tablets to the antibiotic nitrofurantoin for preventing urinary tract infections (UTIs) in women after pelvic organ prolapse or incontinence surgery. About 142 women will be randomly assigned to take either cranberry capsules or nitrofurantoin for a …

This study tests a new collapsible pessary (Reia) for women with pelvic organ prolapse. The goal is to see if it allows patients to care for their prolapse on their own, instead of needing to visit a doctor 2-4 times per year. About 120 current pessary users will try the device a…

This study planned to test whether a special laser could help women with mild to moderate pelvic organ prolapse who had not gotten relief from other treatments. It was designed as a sham-controlled trial, meaning some women would get the real laser and others a fake procedure, to…

This study looks at two surgical methods for pelvic organ prolapse in women: robotic and open surgery. Researchers want to find out which costs more during the operation and how satisfied patients are with their scars and overall results. About 80 women having either type of surg…