OSTEO ARTHRITIS KNEE

This study tests whether a 6-week gait retraining program using real-time feedback can improve walking patterns and reduce early signs of knee osteoarthritis in people who have had ACL reconstruction. 70 participants aged 16-35 will be followed for 6 months. The goal is to see if…

This study tests a new treatment called OA-SYS for people with moderate to severe knee osteoarthritis. The main goal is to see if it is safe and well-tolerated by 400 adults aged 35 to 75. Researchers will also check if it reduces pain and the need for pain relievers. This is an …

This study compares two types of knee replacement surgery for people with advanced knee arthritis: a standard total knee replacement and a robotic-assisted partial knee replacement. The goal is to see which one leads to better knee function and is more cost-effective. About 159 a…

This study tests different types and doses of vitamin K in 55 adults aged 60 and older with knee osteoarthritis. Researchers want to see if vitamin K can improve knee health by measuring changes in blood markers. The goal is to find the best form and dose for future larger studie…

This pilot study tests whether using a whole-body vibration machine at home for 12 weeks can reduce knee pain and inflammation in people with osteoarthritis. Thirty adults aged 40 to 75 with knee pain for at least 6 months will participate. Researchers will measure pain sensitivi…

This study compares two pain-relief methods after total knee replacement: a single injection into the adductor canal versus a continuous nerve block in the thigh. The goal is to see which approach helps patients walk farther and recover faster without increasing fall risk. About …

This study tests whether adding metformin, a diabetes drug, to usual care can reduce pain and improve function in people with knee osteoarthritis. About 70 adults aged 30 to 60 with moderate knee arthritis will take metformin or a placebo alongside their regular treatments. The g…

This study looks at whether a surgical robot (ROSA Knee) can change the bone cut angles and implant fit during knee replacement surgery based on the condition of the soft tissues. About 80 adults with knee arthritis or rheumatoid arthritis will take part and be followed for 2 yea…

This study tests whether adding a special breathing therapy (intermittent hypoxia-hyperoxia) to standard physical therapy can reduce pain and improve movement in people with knee osteoarthritis. Sixty adults aged 45 and older with knee pain for at least 3 months will participate.…

This study tests whether filling the bone gap with a synthetic putty (AttraX Putty) during knee realignment surgery can reduce pain in the first week after surgery. About 40 adults with knee osteoarthritis will be randomly assigned to get the putty or standard surgery without a g…

This study looks at whether adding a special fall prevention program to regular physical therapy can reduce falls and improve balance in older adults who have had a total knee replacement. About 90 women aged 60 and older who had knee replacement surgery will take part. The progr…

This study tests whether a combination of platelet-rich plasma (PRP) and hyaluronic acid (a joint lubricant) works better than either treatment alone for knee osteoarthritis. About 288 adults aged 40-75 with knee pain will receive injections and be monitored for changes in pain, …

This study is testing the safety and effectiveness of the MISHA Knee System, a device implanted to relieve pain and improve function in people with medial knee osteoarthritis. About 120 adults aged 25 to 65 who have not gotten relief from non-surgical treatments will be followed …

This study compares a new hydrogel injection (Arthrosamid) to a standard steroid shot for treating knee osteoarthritis. About 200 adults with knee pain and moderate to severe arthritis will receive one of the two injections. The goal is to see if the hydrogel reduces pain, stiffn…