OSTEO ARTHRITIS KNEE

This early-phase study tested whether a single injection of donor bone-marrow stem cells (StromaForte) is safe for people with mild-to-moderate knee osteoarthritis. Twelve adults received the injection and were monitored for side effects over 24 weeks. The main goal was safety, n…

This study tested whether a device called the OrthoCor Advanced System can reduce pain and improve quality of life in people with knee osteoarthritis. Twenty-three adults with knee pain for at least 3 months used the device for 30 minutes twice daily over 4 weeks. The device deli…

This early study tested whether injecting a special mixture of cells from a person's own belly fat into their arthritic knee is safe and doable. Nine adults with knee osteoarthritis received the injection. The main goal was to check for side effects, not to measure pain relief, s…

This study tested a once-weekly injection called retatrutide in 445 people with obesity or overweight who also have knee osteoarthritis. The goal was to see if it helps with weight loss and reduces knee pain. The trial lasted about 77 weeks and compared the drug to a placebo.

This study tested a hands-on therapy called Mulligan mobilization combined with isometric (static) exercises for people with knee osteoarthritis. Fifty adults aged 40-65 with moderate knee arthritis took part. The goal was to see if this approach could reduce pain, improve moveme…

This study tested a new drug called LEVI-04 to see if it can reduce pain in people with knee osteoarthritis. About 518 adults with knee pain took either the drug or a placebo. The goal was to measure pain changes using a standard knee pain scale. This is not a cure, but aims to e…

This study compared a single injection of sterile amniotic fluid to the standard steroid shot for knee osteoarthritis. 60 adults with moderate knee arthritis who had not gotten relief from other treatments took part. The main goal was to see if the amniotic fluid could reduce the…

This study looked at whether adding deep breathing or simple yoga poses to standard physical therapy could help people with knee osteoarthritis feel less afraid of moving. 40 adults aged 40-60 with severe knee pain took part. The results showed that both approaches helped reduce …

This study tested whether using a cold and compression brace for 6 weeks after knee replacement surgery helps reduce pain and the need for painkillers. 208 adults who had a total or partial knee replacement took part. They used the brace 5 times a day for 20 minutes, and research…

This study tested whether adding a topical anti-inflammatory cream to a supervised exercise program helps knee osteoarthritis pain more than either treatment alone. 79 adults aged 40-65 with moderate knee osteoarthritis took part. The goal was to find the most effective way to ea…

This study tested a movement therapy called Mulligan mobilization in 36 people with knee osteoarthritis. The goal was to see if it could reduce pain and improve how muscles work. Participants were aged 50 to 70 with moderate knee pain. The therapy involves gentle, repeated moveme…

This study tested a two-week home treatment combining gentle brain stimulation (tDCS) with mindfulness meditation in 208 older adults with knee osteoarthritis. The goal was to see if this drug-free approach could reduce pain and improve daily function. Results focused on changes …

This study tested a personalized web-based care plan for over 5,700 adults with knee or hip osteoarthritis. The goal was to help patients and their doctors make more informed decisions about treatments, including whether to have joint replacement surgery. The study measured how w…

This study looked at how well people with knee osteoarthritis perform strength and function tests when they do one task at a time versus two tasks at once. Researchers measured leg muscle strength, sit-to-stand ability, pain, and joint stiffness in 60 adults aged 40-65 with moder…