OLIGOMETASTATIC DISEASE

This study is testing whether a single, high-dose radiation session works as well as multiple sessions for people whose cancer has spread to a few places (oligometastatic disease). About 600 participants will be randomly assigned to receive either one or several radiation treatme…

This study tests whether adding precise, high-dose radiation to cancer spots outside the prostate (called metastases) can help men whose prostate cancer has spread to just a few places. About 122 men with up to 5 metastatic spots will receive standard treatment plus either observ…

This phase 2 trial is testing whether giving the drug niraparib again after surgery can help women with ovarian cancer whose disease has come back in just a few spots. About 30 participants will take niraparib pills daily until their cancer grows or side effects become too much. …

This study tests whether a precise, high-dose radiation technique called SABR works better than standard palliative radiation for people whose cancer has spread to a few new spots while on treatment. About 194 adults with solid tumors (excluding lymphoma or myeloma) and up to 5 g…

This study tests a new type of radiation therapy for prostate cancer that uses an MRI machine to guide the beam in real time. The goal is to deliver high doses of radiation more precisely to the tumor while sparing healthy tissue. The trial will enroll 50 men with localized or li…

This study tests whether adding a drug called ATRA (a form of vitamin A) to standard radiation therapy can prevent a drop in infection-fighting white blood cells in people with a few metastatic tumors. About 58 adults with solid cancers that have spread to up to 5 spots will rece…

This phase II trial is for people with a specific type of non-small cell lung cancer that has spread to only a few places in the body (oligometastatic) and has a driver mutation like EGFR or ALK. Participants have already been on a targeted therapy pill (TKI) for 2-4 months witho…

This phase 3 trial tests whether adding targeted radiation to all cancer spots (up to 5) improves survival in people with non-small cell lung cancer that has spread to a few places. Participants receive either standard maintenance therapy alone or standard therapy plus radiation.…

This pilot study tests whether a faster, simulation-free approach to stereotactic body radiation therapy (SBRT) is safe and feasible for people whose cancer has spread to up to five spots (oligometastatic disease). Instead of requiring a separate planning CT scan and days of prep…

This pilot study will test whether a special PET/MRI scan can detect real-time artery inflammation in the heart after chest radiation therapy. Ten adults with stage II-III or limited stage IV cancer who are at high risk for heart problems will be scanned before and 6 months after…