OLIGODENDROGLIOMA

This study tests whether giving two cancer drugs (cetuximab and bevacizumab) directly into the brain's blood vessels each month is safe and works for children and young adults under 22 whose brain tumors have come back or not responded to treatment. About 20 participants will rec…

This study compares two types of radiation therapy for people with slow-growing brain tumors (IDH-mutated gliomas). Proton therapy aims to better protect healthy brain tissue than standard photon therapy, but it's unclear if it's as effective at controlling the tumor. The trial w…

This study looks at whether waiting to start radiation therapy until the tumor grows can help protect memory and thinking skills in people with a slow-growing brain tumor called low-grade oligodendroglioma. About 280 adults whose tumor has a specific genetic marker (1p/19q codele…

This early-stage trial tests an oral drug called ONC206 in adults with brain tumors that have come back. The main goal is to find the safest dose and understand side effects. About 102 participants will receive the drug weekly or multiple days per week.

This study tests a more intense treatment for a fast-growing type of brain cancer called IDH wildtype glioma. It combines higher doses of radiation with the chemotherapy drug temozolomide to try to stop the tumor from growing longer. The trial will enroll 40 adults with this spec…

This study tests a combination of two drugs—ATRA and retifanlimab—in people with a specific type of brain tumor (IDH-mutant glioma) that has returned after prior treatment. The goal is to see if this combo can shrink tumors or slow their growth by boosting the body's immune respo…

This study tests a drug called safusidenib in people with a slow-growing brain tumor (glioma) that has a specific IDH1 gene mutation. The trial has three parts: one for recurrent tumors, one to see if the drug can prevent tumor growth after standard treatment, and one for a speci…

This study is for adults with a type of brain tumor called oligodendroglioma. The goal is to see if starting with a new chemotherapy combination (CETEG) instead of the standard radiation plus chemo can help people live longer without losing thinking skills or quality of life. Abo…

This study tests a home-based program called HOBSCOTCH-CA to help brain cancer survivors improve their memory, thinking, and quality of life. About 125 participants (including veterans and civilians) will either start the program right away or wait 3 months. The program involves …

This study is testing whether a program called FearLess is practical and well-received by people with primary malignant brain tumors and their caregivers. The goal is to see if the recruitment methods, study design, and program itself work well before a larger trial. About 112 pa…