OBESE

This study tested whether giving rewards like gift cards can help Native American women quit smoking and lose weight. 125 women who smoked daily and were overweight or obese took part. They earned prizes for staying smoke-free and losing a half to one pound per week. The goal was…

This study tested an oral drug called LY3502970 in 72 healthy overweight and obese adults to see if it is safe and how the body processes it. Participants took the drug by mouth, and researchers monitored side effects and drug levels in the blood over up to 42 days. The goal was …

This early-stage trial tested a new drug, RAY1225, in 68 healthy and obese adults in China. The main goal was to check if the drug is safe and how the body processes it. Researchers also looked at changes in body weight and waist size as early signs of effectiveness.

This study tested whether giving a higher dose of oxytocin (a drug that strengthens contractions) could lower the rate of C-sections in obese women having their first baby. Over 400 women took part, receiving either a standard or a higher dose during labour. The goal was to see i…

This study tested whether a natural plant compound called EMIQ can safely help overweight and obese adults lose body fat. Over 12 weeks, 65 participants took either EMIQ or a placebo twice daily. Researchers measured changes in body fat, weight, and other health markers to see if…

This study looked at 90 adults who had bariatric surgery to see if changing the variety of foods they ate affected their food cravings, calorie intake, and weight loss over 12 months. Researchers tracked participants' diets to understand patterns that might help improve long-term…

This completed Phase 1 study looked at how orforglipron, an experimental drug, changes the way the body processes several common medications (digoxin, simvastatin, rosuvastatin, acetaminophen, and midazolam) in 50 healthy overweight or obese adults. The goal was to measure drug l…

This study looked at whether a nutrition and behavior change program could help reduce sleep apnea in people who are overweight or obese. About 400 adults took part, and researchers measured changes in sleep apnea risk, daytime sleepiness, and weight loss. The goal was to see if …

This study looked at how a new drug called GZR18 is processed in the bodies of 6 overweight or obese men. The drug was given as a single injection, and researchers measured how much of it came out in urine and stool over 78 days. The goal was to understand how the drug is broken …

This study tested a device called ANI that measures pain during weight-loss surgery in 15 adults. The goal was to see if using the monitor helps doctors give less morphine. The study is complete and focused on improving pain control during surgery.

This study tested how different coated and uncoated glucose bead formulations affect hormone and blood sugar levels in 20 obese but otherwise healthy adults. Participants took single and multiple doses of glucose beads under fasting conditions. The goal was to understand how the …

This completed study looked at 217 adults with chronic hepatitis B to see how common fatty liver and fatty pancreas are in obese versus lean patients. Researchers used ultrasound and a special liver stiffness test to measure fat and scarring. The goal was to learn more about how …