MORBID OBESITY

This study compares two different doses of the blood thinner bemiparin to see which works better at preventing dangerous blood clots in people with severe obesity after surgery. About 2,400 participants will be enrolled. The goal is to find the safest and most effective dose for …

This study tests a new, personalized version of a weight-loss surgery called SADI-S. Surgeons will measure each patient's small intestine and adjust the bypass length to maximize weight loss while lowering the risk of vitamin deficiencies. The study includes 40 adults with obesit…

This study compares two versions of gastric bypass surgery for people with severe obesity. One method uses fixed lengths for the rerouted intestine, while the other customizes the lengths based on each patient's total small bowel length. The goal is to see if the customized appro…

This study looks at whether continuing GLP-1 medications (like Ozempic or Wegovy) after weight-loss surgery helps people lose more weight and control blood sugar better than stopping them. About 150 adults with severe obesity will be randomly assigned to keep taking the drug or s…

This study follows 50 people who are having either sleeve gastrectomy or gastric bypass for severe obesity. Researchers will check stool samples before and 6 months after surgery for signs of digestion problems and gut inflammation. They want to see if simple stool tests can help…

This study follows 300 people who are having weight-loss (metabolic) surgery to see how their gut bacteria change over time and how those changes relate to heart health, diabetes, and cholesterol. Participants provide blood and stool samples before surgery and at several follow-u…

This study looks at how weight loss surgery changes sexual function, sex hormones, mood, and quality of life in 40 women with severe obesity. Participants complete questionnaires and give blood samples before surgery and 6 months after. Their partners also report on their own sex…

This study follows 35 people with severe obesity who are having mini-gastric bypass surgery as part of their routine care. Researchers want to see how the surgery helps improve related health problems like type 2 diabetes, sleep apnea, high blood pressure, and fatty liver disease…

This study follows 1,000 people who had bariatric surgery 5 years ago to learn why some maintain significant weight loss while others do not. Researchers will track weight, type of surgery, and other factors to improve patient counseling and tailor surgical choices. The goal is t…

This study aims to understand why children with ROHHAD syndrome gain weight very quickly. Researchers will compare the genes and metabolism of affected children with their healthy siblings. No new treatments are being tested; the goal is to learn more about the disease.

This study looks at genetic and biochemical markers in fat tissue from 500 people with severe obesity who are having bariatric surgery. Researchers want to compare tissue from healthy obese patients (without diabetes or other major issues) to those with type 2 diabetes. The goal …