METASTATIC COLORECTAL CARCINOMA

This study tests whether adding a chemotherapy pump that delivers drugs directly to the liver (hepatic arterial infusion) to standard chemotherapy helps people with colorectal cancer that has spread to the liver and cannot be removed by surgery. About 408 adults with cancer only …

This early-phase study is testing whether giving two standard chemotherapy drugs (5FU and oxaliplatin) directly into the abdomen is safe and effective for people with colorectal cancer that has spread only to the belly lining. About 24 adults with this condition will receive the …

This early-stage trial tests the safety and best dose of a new drug called ZEN003694 when given with the standard chemotherapy capecitabine. It is for adults with solid tumors that have spread or can't be removed and have not responded to prior treatments. The goal is to find a d…

This study is for people with advanced gastrointestinal cancers that are spreading and no longer responding to immunotherapy. Researchers want to see if adding targeted radiation to one tumor can help the immune system fight cancer throughout the body. About 28 participants will …

This early-stage study is testing a new method called PIPAC, which turns chemotherapy into a fine mist and sprays it directly into the abdomen during a keyhole surgery. The goal is to see if this approach is safe and can reduce side effects compared to standard chemotherapy. Abou…

This early-phase study tests a new drug that delivers radiation directly to cancer cells in people with advanced solid tumors (like lung, colon, head and neck, pancreatic, stomach, or kidney cancer) that have stopped responding to standard treatments. The main goals are to check …

This study looks at whether giving the cancer drug nivolumab as a shot at home is as good as getting it at the clinic. About 50 adults with various cancers will try both ways to see which they prefer and how it affects their quality of life. The goal is to reduce the time, cost, …

This study tests whether freezing bone tumors (cryoablation) before giving radiation therapy works better than radiation alone for reducing pain. About 40 adults with cancer that has spread to the bones will be enrolled. The goal is to see if the combination provides more complet…

This study uses a special microscope called intravital microscopy (IVM) to watch blood vessels inside solid tumors in real time during surgery. Researchers want to understand how these vessels work, which could help decide if a patient's tumor is likely to respond to certain trea…

This study collects tissue samples from people with various advanced or early-stage cancers to train a new diagnostic platform called Elephas. The goal is to see how accurately it can predict whether a patient will respond to immunotherapy or chemoimmunotherapy. About 324 partici…

This study is testing a special MRI scan called IVIM DWI to see if it can measure how well colorectal cancer that has spread to the liver responds to chemotherapy. About 70 people with treatable liver tumors will get the scan before and after chemo, before surgery. The goal is to…