METASTATIC COLORECTAL CARCINOMA

This early-stage trial aims to find a safe and effective dose of a new drug, ZEN003694, when given with the standard chemotherapy capecitabine. It is for adults with advanced solid tumors (like colorectal cancer) that have spread or cannot be removed by surgery and have worsened …

This study is for people with colon cancer that has spread to the liver and cannot be removed by surgery. It tests if adding a special pump that delivers chemotherapy directly to the liver helps patients live longer than standard chemotherapy alone. The pump is already FDA-approv…

This early-stage study is testing the safety and best dose of a new two-drug combination for people with advanced solid tumors that have a specific marker called HER2. The treatment pairs an existing targeted cancer drug with a new pill that aims to block cancer cells' ability to…

This study is for people with advanced gastrointestinal cancers that have spread and have stopped responding to immunotherapy. Researchers want to see if giving a short, targeted course of radiation to one tumor can 'wake up' the body's immune system to attack all the cancer, inc…

This early-stage study is testing whether delivering two common chemotherapy drugs directly into the abdominal cavity is safe and effective for patients with colorectal cancer that has spread only to the abdominal lining. Researchers will enroll 24 patients to find the right dose…

This early-stage study is testing the safety of a new, minimally invasive procedure called PIPAC. It delivers chemotherapy as a fine mist directly into the abdomen for people with advanced ovarian, uterine, stomach, colon, or appendix cancers that have spread to the abdominal lin…

This is the first study in people for a new radioactive drug called [225Ac]-FPI-2068. It aims to find a safe dose and see how the drug travels in the body of 70 adults with advanced solid tumors that have stopped responding to standard treatments. The main goal is to check safety…

This study is testing whether giving a cancer immunotherapy treatment called nivolumab as an injection at home is a safe and practical alternative to receiving it at a clinic. It aims to see if home treatment reduces the burden of travel and improves quality of life for patients …

This study is testing a new, specialized type of MRI scan to see if it can better measure how well chemotherapy is working for patients with colorectal cancer that has spread to the liver. The scan is done before and after a few rounds of chemo to see if changes in the scan image…

This study is testing if adding a freezing procedure (cryoablation) to standard radiation therapy works better to relieve pain from cancer that has spread to the bones. Researchers will compare the combination treatment to radiation alone in 40 patients with advanced cancers. The…

This study aims to learn more about the tiny blood vessels that feed solid tumors. Researchers will use a special microscope during a patient's standard cancer surgery to see these vessels in real time. The goal is to understand how tumor blood flow works and if it relates to how…

This study aims to collect tumor tissue samples from patients with various cancers to test a new diagnostic platform called Elephas. The goal is to see how accurately this tool can predict whether patients will respond to immunotherapy treatments before they begin. Researchers wi…