MERKEL CELL CARCINOMA

This study tests a treatment made from a patient's own immune cells (tumor-infiltrating lymphocytes, or TILs) combined with chemotherapy and interleukin-2 for people with advanced skin cancers (cutaneous squamous cell carcinoma or Merkel cell carcinoma) that have not responded to…

This study tests an experimental drug called AZD6750, designed to help the immune system fight cancer. It is for adults with advanced solid tumors (like melanoma, lung, or breast cancer) that have spread. The trial will first find the safest dose, then test if it works alone or w…

This study tests whether specially grown donor immune cells (called cytotoxic T lymphocytes) can safely and effectively treat BK and JC virus infections in 100 people with cancer, HIV/AIDS, or organ transplants. These viruses can cause serious problems like kidney damage or brain…

This early-stage study tests a new treatment called MQ710, made from a modified virus, for people with advanced solid tumors that have not responded to standard therapies. The treatment is injected directly into tumors, either alone or with the immunotherapy drug pembrolizumab. T…

This study tests a new drug called GI-101, either alone or with pembrolizumab or lenvatinib, in people with advanced solid tumors (cancers that have spread). The goal is to see if it is safe and works against the cancer. About 317 adults with certain cancers like lung, kidney, or…

This early-phase trial tests a new drug, CRD3874-SI, which aims to activate the immune system to fight advanced solid tumors like sarcoma and Merkel cell carcinoma. Researchers will find the safest dose and check if it shrinks tumors. About 81 adults with cancers that have stoppe…

This study tests an experimental oral drug called NEO212 in people with certain brain tumors (astrocytoma, glioblastoma) or cancers that have spread to the brain. The goal is to find the safest dose and see if it helps control the disease. About 134 adults will take part across t…

This study tests a combination of two FDA-approved drugs—pembrolizumab (an immunotherapy that helps the immune system fight cancer) and lutetium Lu 177 dotatate (a radioactive drug that kills cancer cells)—in about 18 people with Merkel cell carcinoma. The goal is to see if the p…

This study tests whether giving the immunotherapy drug pembrolizumab before and after standard surgery can reduce the chance of Merkel cell carcinoma coming back. About 15 adults with resectable stage I to III cancer will receive one dose before surgery, then continue after. Rese…

This study tests whether a shorter, higher-dose radiation schedule can effectively control Merkel cell carcinoma after surgery. About 52 adults with no signs of cancer spread will receive hypofractionated radiation to the tumor site and nearby lymph nodes. The goal is to see if t…

This study tests a treatment called electrochemotherapy for people with tumors in organs like the liver or pancreas that cannot be removed with surgery. The treatment uses short electric pulses to help chemotherapy drugs enter cancer cells more effectively. The goal is to see if …

This study tests whether adding a drug called tarlatamab to standard radiation therapy is safe and effective for cancers that have a protein called DLL3, such as certain lung cancers, melanomas, and bladder cancers. About 30 adults with advanced or returning cancers will receive …

This study tests whether giving two immunotherapy drugs (nivolumab and relatlimab) before surgery can improve outcomes for people with Merkel cell carcinoma, a rare skin cancer. About 20 adults with stage I to III resectable cancer will receive the drugs for six weeks, then have …

This study compares giving cancer treatment at home versus in a clinic for 27 adults with various cancers in the Florida Panhandle. The goal is to see if patients prefer home care and if it is safe. Participants will receive their usual cancer drugs either at home or in the clini…

This study tests whether EMLA numbing cream can reduce pain from Technetium 99 injections used in lymphoscintigraphy, a standard mapping procedure for skin cancers like melanoma. About 100 adults with skin cancer will receive either EMLA cream or a placebo before the injection. R…

This study aims to see if a new predictive model can accurately tell which patients with melanoma and other skin cancers will respond to immunotherapy. Researchers will collect tumor tissue, blood, and stool samples from 1,000 participants and compare the model's predictions to a…